Recent research has examined Akt and Akt-related serine–threonine kinases in signaling
cascades that regulate cell survival and are important in the pathogenesis of degenerative …

The endothelial nitric oxide synthase (eNOS), the expression of which is regulated by a
range of transcriptional and posttranscriptional mechanisms, generates nitric oxide (NO) in …

Endothelial nitric oxide synthase (eNOS) is essential for neovascularization. Here we show
that the impaired neovascularization in mice lacking eNOS is related to a defect in …

Background—In stable coronary artery disease (CAD), exercise training has well-
documented positive effects on arterial endothelial function. NO derived from endothelial NO …

Adiponectin is secreted by adipose cells and mimics many metabolic actions of insulin.
However, mechanisms by which adiponectin acts are poorly understood. The vascular …

The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the
focus of attention in vascular biology for more than a decade. There is now a consensus that …

Oxidative stress plays a pivotal role in the pathogenesis of atherosclerosis and can be
effectively influenced by radical scavenging enzyme activity and expression. The …

In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-
sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the …

In the past two decades, normal endothelial function has been identified as integral to
vascular health. The endothelium produces numerous vasodilator and vasoconstrictor …

The vascular endothelium is a dynamic endocrine organ that regulates contractile, secretory,
and mitogenic activities in the vessel wall and hemostatic processes within the vascular …