Specific fusion of biological membranes is a central requirement for many cellular
processes. 1 Membrane fusion involves the merging of the membranes of two different …

Modular domains that recognize and target intracellular membranes play a critical role in the
assembly, localization, and function of signaling and trafficking complexes in eukaryotic …

During constitutive endocytosis, internalized membrane traffics through endosomal
compartments. At synapses, endocytosis of vesicular membrane is temporally coupled to …

The nerve growth factor (NGF) family of neurotrophins binds two classes of cell-surface
receptors, trk receptor tyrosine kinases and the shared p75 receptor. Rapid internalization …

The secretory and endocytic pathways of eukaryotic organelles consist of multiple
compartments, each with a unique set of proteins and lipids. Specific transport mechanisms …

Regulated exocytosis was the first intracellular membrane fusion step that was suggested to
involve both Ca2+ and calmodulin. In recent years, it has become clear that calmodulin is …

The Rab5 effector early endosome antigen 1 (EEA1) is a parallel coiled coil homodimer with
an N-terminal C 2 H 2 Zn 2+ finger and a C-terminal FYVE domain. Rab5 binds to …

Ca2+ is an essential requirement in membrane fusion, acting through binding proteins such
as calmodulin (CaM). Ca2+/CaM is required for early endosome fusion in vitro, however, the …

Phosphoinositides play a central role in the control of major eukaryotic cell signaling
mechanisms. Accordingly, the list of phosphoinositide-metabolizing enzymes implicated in …

Early endosome antigen 1 (EEA1) is a target autoantigen in patients diagnosed with
neurological and other autoimmune conditions. Eighteen of 65 sera (28%) that displayed a …