All cells must maintain a high ratio of cellular ATP: ADP to survive. Because of the adenylate
kinase reaction (2ADP↔ ATP+ AMP), AMP rises whenever the ATP: ADP ratio falls, and a …

The AMP-activated protein kinase is a sensor of cellular energy status that is found in all
eukaryotic cells. It is activated by rising AMP and falling ATP by a complex mechanism that …

Mutations in either the TSC1 or TSC2 tumor suppressor gene are responsible for Tuberous
Sclerosis Complex. The gene products of TSC1 and TSC2 form a functional complex and …

Background The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular
energy charge that acts as a'metabolic master switch'and inhibits cell proliferation. Activation …

HSL (hormone-sensitive lipase) is a key enzyme in the mobilization of fatty acids from
acylglycerols in adipocytes as well as non-adipocytes. In adipocytes, catecholamines …

We have proposed the “glucolipotoxicity” hypothesis in which elevated free fatty acids
(FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because …

The effect of exercise intensity on skeletal muscle AMP-activated protein kinase (AMPK)
signaling and substrate metabolism was examined in eight men cycling for 20 min at each of …

AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid
metabolism. To better understand the physiological role of AMPK, we generated a knockout …

Recent studies have indicated that endothelial nitric-oxide synthase (eNOS) is regulated by
reversible phosphorylation in intact endothelial cells. AMP-activated protein kinase (AMPK) …

The transcriptional coactivator the peroxisome proliferator-activated receptor γ coactivator-
1α (PGC-1α) has been identified as an important mediator of mitochondrial biogenesis …