Microparticles are membrane vesicles released from many different cell types. There are two
mechanisms that can result in their formation, cell activation and apoptosis. In these two …

Microparticles are fragments released from the plasma membrane of most stimulated or
apoptotic cells. After having long been considered inert cell debris, of possible value for the …

The molecular mechanisms by which extreme blood pressure elevation leads to vascular
injury are not defined. To explore the hypothesis that activation of endothelium and platelets …

Background: Endothelial cells (EC) shed endothelial microparticles (EMP) in activation and
apoptosis. Objectives: We compared the antigenic expression of EMP species released …

OBJECTIVES: P-selectin inhibition has been found to limit venous thrombosis. We
hypothesize that elevated levels of P-selectin will amplify thrombosis, mediated by …

Background: Endothelial activation and dysfunction are associated with several diseases.
However, hardly any specific markers are available. Microparticles (MP) from endothelial …

It has been suggested that endothelial apoptosis is a primary lesion in the pathogenesis of
thrombotic thrombocytopenic purpura (TTP). We tested this hypothesis by examining the …

Increased generation of oxidants, resulting from disruption of aerobic metabolism and from
respiratory burst, is an essential defense mechanism against pathogens and aberrant cells …

During myocardial infarction (MI), high levels of circulating procoagulant microparticles (MP)
shed from endothelial cells and platelets diffuse prothrombotic and proinflammatory …

Recent evidence indicates that infections or a pathogen burden contribute to the
development and progression of atherosclerosis. While the mechanism of infection …