Duchenne muscular dystrophy (DMD) is a fatal, genetic disorder whose relentless
progression underscores the urgency for developing a cure. Although Duchenne initiated …

Satellite cells are quiescent muscle stem cells that promote postnatal muscle growth and
repair. Here we show that myostatin, a TGF-β member, signals satellite cell quiescence and …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Muscle growth results from a set of complex processes including myogenic transcription
factor's expression and activity, cell cycle withdrawal, myoblast fusion in myotubes, and …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Myostatin is a member of the TGF-β family that functions as a negative regulator of skeletal
muscle development and growth in mammals. Recently, Myostatin has also been identified …

By using a conditional gene targeting approach exploiting the cre‐lox system, we show that
postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a …

Myostatin is hypothesized to regulate skeletal muscle mass and to be a potential target for
therapeutic intervention in sarcopenia. To clarify whether myostatin is invariably associated …

肌肉生长抑制素是控制骨骼肌生长发育的重要细胞因子. 采用PCR-SSCP 和DNA
测序的方法检测了Myostatin 基因单核苷酸多态性, 利用CAU 资源家系对所发现的Myostatin …

Myostatin, a member of the transforming growth factor-β superfamily, is a negative regulator
of skeletal muscle mass in mammals. We have studied myostatin expression during …