Pharmacogenetics of anticancer drug sensitivity in non-small cell lung cancer
In mammalian cells, the process of malignant transformation is characterized by the loss or
down-regulation of tumor-suppressor genes and/or the mutation or overexpression of proto …
down-regulation of tumor-suppressor genes and/or the mutation or overexpression of proto …
Pharmacological basis for cladribine resistance
K Lotfi, G Juliusson, F Albertioni - Leukemia & lymphoma, 2003 - Taylor & Francis
The inherent or acquired resistance of leukemic cells to cytostatic agents is a major clinical
challenge. The purpose of this review was to elucidate and analyse the available data …
challenge. The purpose of this review was to elucidate and analyse the available data …
Deoxycytidine kinase and cN‐II nucleotidase expression in blast cells predict survival in acute myeloid leukaemia patients treated with cytarabine
CM Galmarini, X Thomas, K Graham… - British journal of …, 2003 - Wiley Online Library
The cytotoxic activity of cytarabine (ara‐C) in leukaemic blasts depends on activating
enzymes such as deoxycytidine kinase (dCK) and inactivating enzymes such as the 5 …
enzymes such as deoxycytidine kinase (dCK) and inactivating enzymes such as the 5 …
Role of IMP-selective 5′-nucleotidase (cN-II) in hematological malignancies
CM Galmarini, L Jordheim, C Dumontet - Leukemia & lymphoma, 2003 - Taylor & Francis
Cytotoxic nucleoside analogs (NA) are important in the treatment of hematologic
malignancies. The NA in routine clinical use include the pyrimidine analog cytosine …
malignancies. The NA in routine clinical use include the pyrimidine analog cytosine …
Drug resistance to cytotoxic nucleoside analogues
L Jordheim, CM Galmarini, C Dumontet - Current Drug Targets, 2003 - ingentaconnect.com
Nucleoside analogues are widely used for the treament of hematological malignancies and
solid tumors. Their activity is based on the interference with cellular targets involved in the …
solid tumors. Their activity is based on the interference with cellular targets involved in the …
Spontaneous reversal of p‐glycoprotein expression in multidrug resistant cell lines
Increased expression of P‐glycoprotein encoded by the mdr‐1 gene is a well‐characterised
mechanism for resistance to cancer chemotherapeutic drugs in cell lines. However, the P …
mechanism for resistance to cancer chemotherapeutic drugs in cell lines. However, the P …
[图书][B] The cell cycle phase specificity of DNA damage induced by radiation, peroxide and chemotherapeutic drugs targeting topoisomerase II, and CD4 and CD8 …
AJ Potter - 2003 - search.proquest.com
Drugs targeting topoisomerase II (topoII) are widely used to treat human cancers. Although
cytostasis and cytotoxicity induced by these drugs arise in specific cell cycle phases, it is …
cytostasis and cytotoxicity induced by these drugs arise in specific cell cycle phases, it is …