Metabolic oligosaccharide engineering as a tool for glycobiology
DH Dube, CR Bertozzi - Current opinion in chemical biology, 2003 - Elsevier
Oligosaccharides transact information exchange at the cell surface and modulate the
activities and distribution of proteins within cells. Recently, the ability to modify …
activities and distribution of proteins within cells. Recently, the ability to modify …
A brief history of novel drug discovery technologies
LJ Gershell, JH Atkins - Nature Reviews Drug Discovery, 2003 - nature.com
Laypersons, researchers and clinicians alike speak of the biotechnology revolution with
excitement. Media coverage of new breakthroughs in medicine often have the public and the …
excitement. Media coverage of new breakthroughs in medicine often have the public and the …
Maleimide-functionalized self-assembled monolayers for the preparation of peptide and carbohydrate biochips
BT Houseman, ES Gawalt, M Mrksich - Langmuir, 2003 - ACS Publications
This paper reports a convenient method for immobilizing biologically active ligands to self-
assembled monolayers of alkanethiolates on gold (SAMs). This methodology is based on …
assembled monolayers of alkanethiolates on gold (SAMs). This methodology is based on …
[图书][B] Carbohydrate-based drug discovery, 2 volume set
CH Wong - 2003 - books.google.com
Die Suche nach Medikamenten mit neuen oder verbesserten Eigenschaften hat das
Interesse am pharmazeutischen Potenzial von Kohlenhydraten enorm verstärkt. Dies gilt …
Interesse am pharmazeutischen Potenzial von Kohlenhydraten enorm verstärkt. Dies gilt …
1, 2-cis O-Glycosylation: methods, strategies, principles
AV Demchenko - Current organic chemistry, 2003 - ingentaconnect.com
The aim of this review is to discuss the accomplishments made in the area of the
stereoselective formation of a 1, 2-cis glycosidic bond. Importance of this subject derives …
stereoselective formation of a 1, 2-cis glycosidic bond. Importance of this subject derives …
Stereoselective chemical 1, 2-cis O-glycosylation: from 'sugar ray'to modern techniques of the 21st century
AV Demchenko - Synlett, 2003 - thieme-connect.com
Thieme E-Journals - Synlett / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SYNLETT Full-text search Full-text search Author …
Service Library Service Help Contact Portal SYNLETT Full-text search Full-text search Author …
A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: a case study of vancomycin
TK Ritter, KK Mong, H Liu, T Nakatani… - Angewandte Chemie …, 2003 - scholar.nycu.edu.tw
The notoriously difficult glycosylation of vancomycin was tackled in a one-pot procedure. A
number of oligosaccharides were synthesized and attached to the vancomycin aglycon to …
number of oligosaccharides were synthesized and attached to the vancomycin aglycon to …
Automated carbohydrate synthesis to drive chemical glycomics
PH Seeberger - Chemical communications, 2003 - pubs.rsc.org
This feature article describes the development of the first automated solid-phase
oligosaccharide synthesizer. A series of chemical challenges had to be addressed to …
oligosaccharide synthesizer. A series of chemical challenges had to be addressed to …
“Multivalent” saccharides: development of new approaches for inhibiting the effects of glycosphingolipid-binding pathogens
CL Schengrund - Biochemical Pharmacology, 2003 - Elsevier
A number of diseases are initiated by the adherence of viruses, bacteria, or bacterial toxins
to cell surface carbohydrates, a number of which are components of glycosphingolipids …
to cell surface carbohydrates, a number of which are components of glycosphingolipids …
Unusual α-glycosylation with galactosyl donors with a C2 ester capable of neighboring group participation
L Chen, F Kong - Tetrahedron letters, 2003 - Elsevier
Glycosylation of 4-methoxyphenyl 2, 3, 6-tri-O-benzoyl-β-d-glucopyranoside (2) with
isopropyl 3-O-allyl-2, 4, 6-tri-O-benzoyl-(9) or 6-O-allyl-2, 3, 4-tri-O-benzoyl-1-thio-β-d …
isopropyl 3-O-allyl-2, 4, 6-tri-O-benzoyl-(9) or 6-O-allyl-2, 3, 4-tri-O-benzoyl-1-thio-β-d …