Until recently, heat shock proteins (also known as heat stress proteins) have mostly been
regarded as intracellular molecules that mediate a range of essential housekeeping and …

Abstract Heatshock proteins (HSPs), or stress proteins, are highly conserved and present in
all organisms and in all cells of all organisms. Selected HSPs, also known as chaperones …

Mast cells (MCs) are considered major players in IgE-mediated allergic responses, but have
also recently been recognized as active participants in innate as well as specific immune …

This article reviews the immunologic basis of clinical trials that test means of tumor antigen
recognition and immune activation, with the goal to provide the clinician with a mechanistic …

The processing of amyloid precursor protein (APP) generates amyloid-β (Aβ) peptides 1–40
and 1–42. The latter is neurotoxic and its accumulation results in amyloid fibril formation and …

Pathogens or pathogen-associated molecular patterns can signal to cells of the innate
immune system and trigger effective adaptive immunity. However, relatively little is known …

Heat shock proteins (hsps) are among the most abundant intracellular proteins. Their
synthesis is rapidly up-regulated by various 'stressors' including temperature, glucose …

gp96 (GRP94) elicits antigen-presenting cell (APC) activation and can direct peptides into
the cross-presentation pathways of APC. These responses arise through interactions of …

Prophylactic tumor vaccination against subsequent tumor challenge depends on effective
crosspriming in vivo. Professional APCs process tumor antigens from whole tumor cells …

Heat shock protein (HSP) 60 nonspecifically activates cells of the innate immune system. In
the present study, we characterized the effects of human HSP60 maturation, cytokine …