The circadian rhythms are daily oscillations in various biological processes that are
regulated by an endogenous clock. Disruption of these rhythms has been associated with …

The circadian system actively synchronizes the temporal sequence of biological functions
with the environment. The oscillatory behavior of the system ensures that entrainment is not …

We present a computational model for the mammalian circadian clock based on the
intertwined positive and negative regulatory loops involving the Per, Cry, Bmal1, Clock, and …

Animal behavior is synchronized to the 24-hour light: dark (LD) cycle by regulatory programs
that produce circadian fluctuations in gene expression throughout the body. In mammals, the …

Light is a prominent stimulus that synchronizes endogenous circadian rhythmicity to
environmental light/dark cycles. Nocturnal light elevates mRNA of the Period1 (Per1) gene …

Within the suprachiasmatic nucleus (SCN) of the mammalian hypothalamus is a circadian
pacemaker that functions as a clock. Its endogenous period is adjusted to the external 24-h …

The suprachiasmatic nucleus (SCN) is the neuroanatomical locus of the mammalian
circadian pacemaker. Here we demonstrate that an abrupt shift in the light/dark (LD) cycle …

Because angiogenesis is essential for tumor growth and metastasis, inhibition of
angiogenesis has emerged as a new therapy to treat cancers. Hypoxia-induced expression …

The circadian clock provides a temporal structure that modulates biological functions from
the level of gene expression to performance and behaviour. Pioneering work on the fruitfly …

The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm
researchers over several decades. Behavioral, genetic, and molecular studies helped to …