Recent studies of moonlighting functions and catalytic promiscuity provide insights into the
structural and mechanistic bases of these phenomena. Moonlighting proteins that are …

The (β/α) 8-barrel is the most common fold in structurally characterized enzymes. Whether
the functionally diverse enzymes that share this fold are the products of either divergent or …

The members of the mechanistically diverse,(β/α) 8-barrel fold-containing enolase
superfamily evolved from a common progenitor but catalyze different reactions using a …

In contrast to kinetic resolution, where only 50% of the racemic starting material can be
converted into the desired product and where the remaining 'wrong'enantiomer has to be …

Bacterial enzymes of the menaquinone (Vitamin K 2) pathway are potential drug targets
because they lack human homologs. MenB, 1, 4-dihydroxy-2-naphthoyl-CoA synthase, the …

Various soil bacteria use 1, 3-dichloropropene, a component of the commercially available
fumigants Shell DD and Telone II, as a sole source of carbon and energy. One enzyme …

Questions are being asked about how enzyme function is described at the molecular level
and the strengths and weaknesses of the EC system for this purpose. A new approach to …

4-Oxalocrotonate tautomerase (4-OT) catalyzes the conversion of 2-oxo-4 E-hexenedioate
to 2-oxo-3 E-hexenedioate through the intermediate, 2-hydroxy-2, 4 E-hexadienedioate. 4 …

o-Succinylbenzoate synthase (OSBS) from Escherichia coli, a member of the enolase
superfamily, catalyzes an exergonic dehydration reaction in the menaquinone biosynthetic …

(1 R, 6 R)-2-Succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate (SHCHC) synthase, or
MenD, catalyzes the thiamin diphosphate-(ThDP-) dependent decarboxylation of 2 …