Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly

M Ramos-Casals, M Garcia-Carrasco, MP Brito… - Lupus, 2003 - journals.sagepub.com
The immune system undergoes continuousmorphologic and functionalchanges
throughoutthe years, and it is now believed that the immune response has its peak function …

Pharmacology and therapeutic effects of dehydroepiandrosterone in older subjects

S Legrain, L Girard - Drugs & aging, 2003 - Springer
Man and higher primates have adrenals that secrete large amounts of
dehydroepiandrosterone (DHEA)[prasterone] and its sulphate (DHEAS)[PB 008]. A …

Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis

H Saito, ER Sherwood, TK Varma, BM Evers - Mechanisms of ageing and …, 2003 - Elsevier
Aging is accompanied by an altered stress response that underlies increased susceptibility
of the elderly patients to physiological stress such as infection and sepsis. In the present …

Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for …

IM Rea, OA Ross, M Armstrong, S McNerlan… - Mechanisms of ageing …, 2003 - Elsevier
In this study, we have assessed any change in the frequency of the GG homozygotes of the
174 IL-6 polymorphism with increasing age, arguing that if IL-6 tracks with functional …

Disordered hematopoiesis and myelodysplasia in the elderly

G Rothstein - Journal of the American Geriatrics Society, 2003 - Wiley Online Library
Normal hematopoiesis constitutes the process of producing diverse, differentiated blood cell
types in a manner related to physiological requirement. During aging, modulation of …

Role of redox imbalance in the molecular mechanisms responsible for immunosenescence

RA Daynes, EY Enioutina, DC Jones - Antioxidants and redox …, 2003 - liebertpub.com
The elderly suffer impairments to their immune system, evidenced by higher susceptibility to
infections, cancer, and many diseases believed to be autoimmune in nature. A dysregulated …

Immunology in anxiety and depression

S Andreas, H Florian - Handbook of depression and anxiety, 2003 - taylorfrancis.com
The objectives of psychoneuroimmunology are to elucidate the reciprocal influences of the
nervous system and the immune system and their effects on behavior and health. This field …

Telomerase upregulates expression levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, and granulocyte–macrophage colony-stimulating factor in normal human fibroblasts

Y Kanzaki, F Onoue, H Sakurai, T Ide - Biochemical and biophysical …, 2003 - Elsevier
Expression of human telomerase reverse transcriptase (hTERT) in normal human fibroblast
cell strain, TIG-3, extends their replicative life span. We found that expression levels of …

Role of the cytokine network in major psychoses

N Müller, MJ Schwarz - Advances in Molecular and Cell Biology, 2003 - Elsevier
Publisher Summary This chapter discusses the recent advances in immunological research
regarding the differentiation between type-1 and type-2 immune response, and specific and …

The role of nutrition in immunity of the aged

S Walrand, MP Vasson… - Gut Flora, Nutrition …, 2003 - Wiley Online Library
Improvements in health care and nutrition in the last century have increased most people's
life expectancy. One result is that the elderly are now the fastest-growing segment of the …