The nuclear lamina is a structure near the inner nuclear membrane and the peripheral
chromatin. It is composed of lamins, which are also present in the nuclear interior, and lamin …

Mechanisms for nuclear migration and nuclear anchorage function together to control
nuclear positioning. Both tubulin and actin networks play important roles in nuclear …

The nucleoskeleton is composed of many interacting structural proteins that provide the
framework for DNA replication, transcription and a variety of other nuclear functions. For …

Most inherited diseases are associated with mutations in a specific gene. Sometimes,
mutations in two or more different genes result in diseases with a similar phenotype. Rarely …

Mutations in the LMNA gene encoding nuclear lamins A and C are responsible for seven
inherited disorders affecting specific tissues. We have analyzed skin fibroblasts from a …

Emerin is a nuclear envelope protein whose biological function remains to be elucidated.
Mutations of emerin gene cause the Emery-Dreifuss muscular dystrophy, a neuromuscular …

Emerin is a nuclear membrane protein that interacts with lamin A/C at the nuclear envelope.
Mutations in either emerin or lamin A/C cause Emery–Dreifuss muscular dystrophy (EDMD) …

Background Mutations in the gene encoding the nuclear membrane protein lamin A/C have
been associated with at least 7 distinct diseases including autosomal dominant dilated …

Genetic studies of cardiomyopathy and muscular dystrophy have emphasized the
importance of the striated myocyte cytoskeleton. Cytoskeletal defects produce myopathies …