In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the alveoli
because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …

Neonatal lung diseases may have a genetic background. The available studies mainly
concentrate on surfactant proteins (SP-A, SP-B) and respiratory distress syndrome. Specific …

SP-C-deficient (SP-C−/−) mice developed a severe pulmonary disorder associated with
emphysema, monocytic infiltrates, epithelial cell dysplasia, and atypical accumulations of …

Derangement in pulmonary surfactant or its components and alveolar collapse are common
findings in idiopathic pulmonary fibrosis (IPF). Surfactant proteins play important roles in …

Surfactant Protein C (SP-C) is a secreted transmembrane protein that is exclusively
expressed by alveolar type II epithelial cells of the lung. SP-C associates with surfactant …

Human surfactant protein C (hSP-C) is synthesized by the alveolar type 2 cell as a 197
amino acid integral membrane proprotein and proteolytically processed to a secreted 3.7 …

'l9l~ amino acid proprotein with alternative splicing). Sur—factant protein C precursor protein
is an integral membrane protein that is anchored in the membrane by the hydropho—bic …

Introduction 3. Cell/tissue-specific expression of surfactant protein genes 4. Developmental
regulation of surfactant protein gene expression 5. Multifactorial regulation of surfactant …

Lung disease is a major indication for the admittance of the neonate to a specialist intensive
care unit, and is a particularly common complication in the pre-term baby where the lungs …

We have analyzed surfactant protein B (SP‐B) and its encoding gene (SFTPB, MIM 178640)
in 40 unrelated pediatric patients with unexplained respiratory distress (URD). There was …