Gene silencing in cancer in association with promoter hypermethylation
This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …
DNA methylation in serum of breast cancer patients: an independent prognostic marker
HM Muller, A Widschwendter, H Fiegl, L Ivarsson… - Cancer research, 2003 - AACR
Abstract Changes in the status of DNA methylation are one of the most common molecular
alterations in human neoplasia. Because it is possible to detect these epigenetic alterations …
alterations in human neoplasia. Because it is possible to detect these epigenetic alterations …
DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma
MJ Fackler, M McVeigh, E Evron… - … journal of cancer, 2003 - Wiley Online Library
Little is known about epigenetic silencing of genes by promoter hypermethylation in lobular
breast cancers. The promoter methylation status of 5 cancer‐related genes (RASSF1A, HIN …
breast cancers. The promoter methylation status of 5 cancer‐related genes (RASSF1A, HIN …
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma
R Dammann, U Schagdarsurengin, L Liu, N Otto… - Oncogene, 2003 - nature.com
Recently, we have characterized the Ras association domain family 1A gene (RASSF1A) at
the segment 3p21. 3, which is frequently lost in variety of human cancers and epigenetically …
the segment 3p21. 3, which is frequently lost in variety of human cancers and epigenetically …
Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma
U Schagdarsurengin, L Wilkens, D Steinemann… - Oncogene, 2003 - nature.com
Aberrant promoter methylation is a fundamental mechanism of inactivation of tumor
suppressor genes in cancer. The Ras association domain family 1A gene (RASSF1A) is …
suppressor genes in cancer. The Ras association domain family 1A gene (RASSF1A) is …
Control of microtubule stability by the RASSF1A tumor suppressor
The RAS association domain family 1A (RASSF1A) gene is silenced by DNA methylation in
over 50% of all solid tumors of different histological types. However, the biochemical function …
over 50% of all solid tumors of different histological types. However, the biochemical function …
Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis
R Dammann, U Schagdarsurengin… - Histology and …, 2003 - digitum.um.es
The Ras GTPases are a superfamily of molecular switches that regulate cellular proliferation
and apoptosis in response to extra-cellular signals. The regulation of these pathways …
and apoptosis in response to extra-cellular signals. The regulation of these pathways …
Epigenetic Inactivation of RAS Association Domain Family Protein 1 (RASSF1A) in Malignant Cutaneous Melanoma
Recent findings have shown the inactivation of a Ras effector homologue gene referred to
as the Ras association domain family 1 (RASSF1) gene, which is a potential human tumor …
as the Ras association domain family 1 (RASSF1) gene, which is a potential human tumor …
SLIT2 Axon Guidance Molecule Is Frequently Inactivated in Colorectal Cancer and Suppresses Growth of Colorectal Carcinoma Cells
We have shown recently that SLIT2 has tumor suppressor activity and that it is epigenetically
silenced in> 40% of lung and breast tumors. In this study, we have analyzed the methylation …
silenced in> 40% of lung and breast tumors. In this study, we have analyzed the methylation …
Frequent epigenetic inactivation of the SLIT2 gene in gliomas
The SLIT family of genes consists of large extracellular matrix-secreted and membrane-
associated glycoproteins. The Slits (Slit1–3) are ligands for the repulsive guidance …
associated glycoproteins. The Slits (Slit1–3) are ligands for the repulsive guidance …