Immune functions encoded by the natural killer gene complex
WM Yokoyama, BFM Plougastel - Nature Reviews Immunology, 2003 - nature.com
There has been marked progress in our understanding of the role of natural killer (NK) cells
in immune responses, mainly due to the identification of NK-cell receptors and their ligands …
in immune responses, mainly due to the identification of NK-cell receptors and their ligands …
[HTML][HTML] The KIR gene cluster
M Carrington, P Norman - 2003 - ncbi.nlm.nih.gov
Killer cell immunoglobulin-like receptors (KIRs) are members of a group of regulatory
molecules found on subsets of lymphoid cells. They were first identified by their ability to …
molecules found on subsets of lymphoid cells. They were first identified by their ability to …
Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb
The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major
histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC …
histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC …
Regulation of natural killer cell function
AP Makrigiannis, SK Anderson - Cancer biology & therapy, 2003 - Taylor & Francis
Individuals lacking natural killer (NK) cells have persistent viral infections and as a
consequence die prematurely. In addition, mice with decreased NK cell function are more …
consequence die prematurely. In addition, mice with decreased NK cell function are more …
Activating and inhibitory receptors and their role in natural killer cell function
RM Srivastava, B Savithri, A Khar - 2003 - nopr.niscpr.res.in
Last decade has seen a significant advancement in our understanding of the Natural Killer
(NK) cell biology and function. Several receptors present on NK cells have been identified …
(NK) cell biology and function. Several receptors present on NK cells have been identified …
Ly49E expression points toward overlapping, but distinct, natural killer (NK) cell differentiation kinetics and potential of fetal versus adult lymphoid progenitors
F Stevenaert, K Van Beneden… - Journal of Leucocyte …, 2003 - academic.oup.com
Using a new antibody, we found previously that contrary to adult natural killer (NK) cells,
fetal NK cells have a unique phenotype, as they exclusively express Ly49E. This can be …
fetal NK cells have a unique phenotype, as they exclusively express Ly49E. This can be …
MHC‐dependent and ‐independent modulation of endogenous Ly49 receptors on NK1.1+ T lymphocytes directed by T‐cell receptor type
M Sköld, M Stenström, S Sidobre, P Höglund… - …, 2003 - Wiley Online Library
Natural killer (NK) T lymphocytes are thought to act as regulatory cells directing early events
during immune responses. Murine NKT cells express inhibitory receptors of the Ly49 family …
during immune responses. Murine NKT cells express inhibitory receptors of the Ly49 family …
Antibodies to Ly49E and CD94/NKG2 receptors
K Van Beneden, J De Boever… - US Patent App. 10 …, 2003 - Google Patents
0.003 Natural killer cells are capable of lysing tumor and viral-infected cells that lack Major
Histocompatibility Comples (MHC) Antigens (1, 2). NK cells also mediate “hybrid resistance” …
Histocompatibility Comples (MHC) Antigens (1, 2). NK cells also mediate “hybrid resistance” …
KIR enrichment at the effector‐target cell interface is more sensitive than signaling to the strength of ligand binding
PD Borszcz, M Peterson, L Standeven… - European journal of …, 2003 - Wiley Online Library
Target cell lysis by natural killer cells is inhibited by killer cell immunoglobulin‐like receptors
(KIR) that bind major histocompatibility complex class I molecules. Many lymphocyte …
(KIR) that bind major histocompatibility complex class I molecules. Many lymphocyte …
Receptor glycosylation regulates Ly-49 binding to MHC class I
LH Mason, J Willette-Brown, SK Anderson… - The Journal of …, 2003 - journals.aai.org
Murine NK cells express the Ly-49 family of class I MHC-binding receptors that control their
ability to lyse tumor or virally infected host target cells. X-ray crystallography studies have …
ability to lyse tumor or virally infected host target cells. X-ray crystallography studies have …