Chronic obstructive pulmonary disease: molecular and cellularmechanisms

PJ Barnes, SD Shapiro… - European Respiratory …, 2003 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …

COPD exacerbations: definitions and classifications

S Burge, JA Wedzicha - European Respiratory Journal, 2003 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is defined independently of exacerbations,
which are largely a feature of moderate-to-severe disease. This article is the result of a …

Risk factors of readmission to hospital for a COPD exacerbation: a prospective study

J Garcia-Aymerich, E Farrero, MA Felez, J Izquierdo… - Thorax, 2003 - thorax.bmj.com
Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are a leading
cause of admission to hospital among men in many countries, although the factors causing …

Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial

P Calverley, R Pauwels, J Vestbo, P Jones, N Pride… - The Lancet, 2003 - thelancet.com
Background Inhaled longacting β 2 agonists improve lung function and health status in
symptomatic chronic obstructive pulmonary disease (COPD), whereas inhaled …

Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease

W Szafranski, A Cukier, A Ramirez… - European …, 2003 - Eur Respiratory Soc
The efficacy and safety of budesonide/formoterol in a single inhaler compared with placebo,
budesonide and formoterol were evaluated in patients with moderate-to-severe chronic …

Maintenance therapy with budesonide and formoterol in chronicobstructive pulmonary disease

PM Calverley, W Boonsawat, Z Cseke… - European …, 2003 - Eur Respiratory Soc
Lung function in chronic obstructive pulmonary disease (COPD) can be improved acutely by
oral corticosteroids and bronchodilators. Whether clinical improvement can be maintained …

Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study

G Rohde, A Wiethege, I Borg, M Kauth, TT Bauer… - Thorax, 2003 - thorax.bmj.com
Background: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are
a common cause of hospital admission. Many exacerbations are believed to be due to upper …

Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I

MA Spruit, R Gosselink, T Troosters, A Kasran… - Thorax, 2003 - thorax.bmj.com
Background: Chronic obstructive pulmonary disease (COPD) is often associated with
peripheral muscle weakness, which is caused by several factors. Acute exacerbations may …

Airway Bacterial Load and FEV1 Decline in Patients with Chronic Obstructive Pulmonary Disease

TMA Wilkinson, IS Patel, M Wilks… - American journal of …, 2003 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline
in lung function and progressive airway inflammation. Bacteria have been isolated from the …

Exacerbations of chronic obstructive pulmonary disease

JA Wedzicha, GC Donaldson - Respiratory care, 2003 - rc.rcjournal.com
Exacerbations of chronic obstructive pulmonary disease (COPD) cause morbidity, hospital
admissions, and mortality, and strongly influence health-related quality of life. Some patients …