The inflammatory response is a highly regulated physiological process that is critically
important for homeostasis. A precise physiological control of inflammation allows a timely …

The information contained within the linear sequence of bases (the genome) must be
faithfully replicated in each cell cycle, with a balance of constancy and variation taking place …

Transcriptional activation of a gene involves an orchestrated recruitment of components of
the basal transcription machinery and intermediate factors, concomitant with an alteration in …

We have developed a self-assembly system for nucleosome arrays in which recombinant,
post-translationally unmodified histone proteins are combined with DNA of defined …

The organization of multiple mitochondrial DNA (mtDNA) molecules in discrete protein-DNA
complexes called nucleoids is well studied in Saccharomyces cerevisiae. Similar structures …

Postnatal cardiac myocytes respond to stress signals by hypertrophic growth and activation
of a fetal gene program. Recently, we showed that class II histone deacetylases (HDACs) …

Abstract Background Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of
core histones modulating chromatin structure and affecting gene expression. These …

The methylation of lysine residues on histone tails is catalyzed by proteins containing a
conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a …

The fate of the cell relies on a delicate balance between gene expression and repression.
The transcriptional control of the genome is maintained not only by transcription factors but …

The targeted acetylation status of histones and several other transcriptional regulatory
proteins plays an important role in gene expression, although the mechanism for this is not …