The evolutionary genomics of pathogen recombination
P Awadalla - Nature Reviews Genetics, 2003 - nature.com
A pressing problem in studying the evolution of microbial pathogens is to determine the
extent to which these genomes recombine. This information is essential for locating …
extent to which these genomes recombine. This information is essential for locating …
New approaches in vaccine development
C Leclerc - Comparative immunology, microbiology and infectious …, 2003 - Elsevier
In the last century, vaccines have been one of the most powerful tools for preventing
infectious diseases. Smallpox has been eradicated and other diseases such as poliomyelitis …
infectious diseases. Smallpox has been eradicated and other diseases such as poliomyelitis …
Serum IgG3 to the Plasmodium falciparum merozoite surface protein 2 is strongly associated with a reduced prospective risk of malaria
WG Metzger, DMN Okenu, DR Cavanagh… - Parasite …, 2003 - Wiley Online Library
The merozoite surface protein 2 (MSP2) of Plasmodium falciparum is recognized by human
antibodies elicited during natural infections, and may be a target of protective immunity. In …
antibodies elicited during natural infections, and may be a target of protective immunity. In …
Geographical Structure of Diversity and Differences between Symptomatic and Asymptomatic Infections for Plasmodium falciparum Vaccine Candidate AMA1
A Cortés, M Mellombo, I Mueller, A Benet… - Infection and …, 2003 - Am Soc Microbiol
Plasmodium falciparum apical membrane antigen 1 (AMA1) is a prime malaria vaccine
candidate. Antigenic diversity within parasite populations is one of the main factors …
candidate. Antigenic diversity within parasite populations is one of the main factors …
Evidence for Diversifying Selection on Erythrocyte-Binding Antigens of Plasmodium falciparum and P. vivax
Malaria parasite antigens involved in erythrocyte invasion are primary vaccine candidates.
The erythrocyte-binding antigen 175K (EBA-175) of Plasmodium falciparum binds to …
The erythrocyte-binding antigen 175K (EBA-175) of Plasmodium falciparum binds to …
Allele frequency-based analyses robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen
SD Polley, W Chokejindachai, DJ Conway - Genetics, 2003 - academic.oup.com
The Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading candidate for a
malaria vaccine. Here, within-population analyses of alleles from 50 Thai P. falciparum …
malaria vaccine. Here, within-population analyses of alleles from 50 Thai P. falciparum …
Diversity and natural selection in Plasmodium vivax Duffy binding protein gene
J Cole-Tobian, CL King - Molecular and biochemical parasitology, 2003 - Elsevier
The Plasmodium vivax Duffy binding protein (DBP) binds to the Duffy blood group antigen
on the surface of erythrocytes and is essential for invasion. Natural immunity develops to this …
on the surface of erythrocytes and is essential for invasion. Natural immunity develops to this …
Sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-1 (MSP-1) of Plasmodium falciparum
MU Ferreira, WL Ribeiro, AP Tonon, F Kawamoto… - Gene, 2003 - Elsevier
The merozoite surface protein-1 (MSP-1) of the malaria parasite Plasmodium falciparum is a
major blood-stage antigen containing highly polymorphic tripeptide repeats in the domain …
major blood-stage antigen containing highly polymorphic tripeptide repeats in the domain …
Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax
X Feng, JM Carlton, DA Joy, J Mu… - Proceedings of the …, 2003 - National Acad Sciences
The study of genetic variation in malaria parasites has practical significance for developing
strategies to control the disease. Vaccines based on highly polymorphic antigens may be …
strategies to control the disease. Vaccines based on highly polymorphic antigens may be …
Repeat Sequences in Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Targets of Antibodies Associated with Protection from Malaria
SD Polley, KKA Tetteh, DR Cavanagh… - Infection and …, 2003 - Am Soc Microbiol
Human antibodies to the block 2 region of Plasmodium falciparum merozoite surface protein
1 (MSP1) are associated with a reduced prospective risk of clinical malaria. Block 2 is highly …
1 (MSP1) are associated with a reduced prospective risk of clinical malaria. Block 2 is highly …