1. Introduction 3082. Plan of this article 3123. Natural mechanisms of development of novel
protein functions 3133.1 Divergence 3133.2 Recruitment 3163.3 'Mixing and matching'of …

Comparative genomics, using computational and experimental methods, enables the
identification of a minimal set of genes that is necessary and sufficient for sustaining a …

Cytoscape is an open source software project for integrating biomolecular interaction
networks with high-throughput expression data and other molecular states into a unified …

The identification of orthologous groups is useful for genome annotation, studies on
gene/protein evolution, comparative genomics, and the identification of taxonomically …

Background The availability of multiple, essentially complete genome sequences of
prokaryotes and eukaryotes spurred both the demand and the opportunity for the …

Functional links between proteins can often be inferred from genomic associations between
the genes that encode them: groups of genes that are required for the same function tend to …

Background Vibrio parahaemolyticus, a gram-negative marine bacterium, is a worldwide
cause of food-borne gastroenteritis. V parahaemolyticus strains of a few specific serotypes …

For intracellular pathogens such as Salmonellae, Mycobacteriae and Brucellae, infection
requires adaptation to the intracellular environment of the phagocytic cell. The transition …

A survey of the dog genome sequence (6.22 million sequence reads; 1.5× coverage)
demonstrates the power of sample sequencing for comparative analysis of mammalian …

The hyperthermophile Nanoarchaeum equitans is an obligate symbiont growing in coculture
with the crenarchaeon Ignicoccus. Ribosomal protein and rRNA-based phylogenies place …