Neonatal lung diseases may have a genetic background. The available studies mainly
concentrate on surfactant proteins (SP-A, SP-B) and respiratory distress syndrome. Specific …

SP-C-deficient (SP-C−/−) mice developed a severe pulmonary disorder associated with
emphysema, monocytic infiltrates, epithelial cell dysplasia, and atypical accumulations of …

Surfactant Protein C (SP-C) is a secreted transmembrane protein that is exclusively
expressed by alveolar type II epithelial cells of the lung. SP-C associates with surfactant …

Human surfactant protein C (hSP-C) is synthesized by the alveolar type 2 cell as a 197
amino acid integral membrane proprotein and proteolytically processed to a secreted 3.7 …

Idiopathic pulmonary fibrosis (IPF), synonymous with cryptogenic fibrosing alveolitis (CFA),
is a progressive and usually fatal disease of unknown cause characterized by sequential …

Surfactant protein C (SP-C) is a lung-specific protein that is synthesized as a 21-kDa integral
membrane propeptide (pro-SP-C) and proteolytically processed to a 3.7-kDa secretory …

Idiopathic interstitial pneumonias (IIP) include a group of nonneoplastic, noninfectious lung
diseases with a diverse spectrum of pulmonary abnormalities. The term is somewhat …

Identifying genetic determinants of pulmonary fibrosis is at an early stage of evolution. It is
now well recognized that" pulmonary fibrosis" covers a broad range of lung diseases …

Insights into the pathogenesis of idiopathic pulmonary fibrosis (IPF) and the strategies for
treatment of this disorder have evolved over the past 30 years. In the pregenetic era, prior to …