The cell-membrane folate receptor is a potential molecular target for tumor-selective drug
delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review …

Differential expression of folate receptor has been exploited to target liposomes to tumors.
Astrogliomas express low folate receptor levels and are typically surrounded by normal cells …

Vitamin H (biotin) was incorporated into a hydrophobically modified polysaccharide, pullulan
acetate (PA), in order to improve the cancer-targeting activity and internalization of self …

The objective of this study was to investigate the use of folate-targeted liposomes for the
delivery of encapsulated oligonucleotides to folate receptor (FR)-positive tumor cells in vitro …

To avoid systemic toxicity of the cytotoxic drug methotrexate (MTX) and to improve tumor
selectivity, MTX was bound to human serum albumin (HSA) as a drug carrier. To understand …

Aims: Folate receptors (FRs) mediate cellular uptake of folates in many cancer cells and in
folate deficiency heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) mediates …

The new concept developed in this study is the preparation of a new derivative of erythrocyte
ghosts, ie, membrane vesicles loaded with doxorubicin (Dox) HCl and coupled to folic acid …

We describe a technology for attaching libraries of synthetic compounds to coat proteins of
bacteriophage particles such that the identity of the chemical structure is encoded in the …

Controlling the size of condensed DNA particles is a key determinant for their diffusion in
vivo as well as for gene delivery to target cells. Towards this goal, DNA molecules were …

Publisher Summary Synthetic DNA delivery agents are of great interest as alternatives to
viral vectors because they display potentially fewer risks in terms of immunogenicity and …