Update on glucocorticoid action and resistance

HS Nelson, DYM Leung, JW Bloom - Journal of allergy and Clinical …, 2003 - Elsevier
Continuing Medical Education examination CONTINUING MEDICAL EDUCATION
ARTICLECredit can now be obtained, free for a limited time, by reading the following review …

Inhaled corticosteroids: past lessons and future issues

DB Allen, L Bielory, H Derendorf, R Dluhy… - Journal of Allergy and …, 2003 - Elsevier
Inhaled corticosteroids play a pivotal role in the treatment of asthma. Inhalation permits
effective delivery of the corticosteroid in high concentration to target sites within the lung …

Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children

RC Strunk, SJ Szefler, BR Phillips, RS Zeiger… - Journal of allergy and …, 2003 - Elsevier
BACKGROUND: Exhaled nitric oxide (eNO) is a noninvasive test that measures airway
inflammation. Insufficient information is available concerning correlations between eNO and …

Potential adverse effects of the inhaled corticosteroids

HW Kelly, HS Nelson - Journal of Allergy and Clinical Immunology, 2003 - Elsevier
The purpose of this review is to provide the clinician with an update on the potential adverse
effects caused by the inhaled corticosteroids (ICSs). The systemic effects of ICSs are a result …

Mechanisms of severe asthma

S Wenzel - Clinical & Experimental Allergy, 2003 - Wiley Online Library
The mechanisms behind the development of severe asthma are poorly understood.
However, these patients disproportionately consume healthcare resources related to …

Exhaled nitric oxide in asthma: from bench to bedside

CA Bates, PE Silkoff - Journal of allergy and clinical immunology, 2003 - Elsevier
With more than 600 publications, exhaled nitric oxide (NO) has been extensively
investigated as a noninvasive marker of airway inflammation in a research setting. This …

Pharmacology of airway inflammation in asthma and COPD

G Caramori, I Adcock - Pulmonary pharmacology & therapeutics, 2003 - Elsevier
The current asthma therapies are not cures and symptoms return soon after treatment is
stopped even after long term treatment. Although inhaled glucocorticoids are highly effective …

Asthma variability in patients previously treated with β2-agonists alone

WJ Calhoun, LB Sutton, A Emmett… - Journal of allergy and …, 2003 - Elsevier
BACKGROUND: According to national asthma guidelines, asthma severity can be classified
as intermittent, mild, moderate, or severe on the basis of lung function, symptoms, nighttime …

Nitric oxide in allergic airway inflammation

DNR Payne - Current opinion in allergy and clinical immunology, 2003 - journals.lww.com
There is good evidence that exhaled nitric oxide reflects eosinophilic airway inflammation in
asthma. Well designed, long-term studies are needed to evaluate whether the addition of …

Steroid-sparing effects of fluticasone propionate 100 μg and salmeterol 50 μg administered twice daily in a single product in patients previously controlled with …

W Busse, SM Koenig, J Oppenheimer, SA Sahn… - Journal of allergy and …, 2003 - Elsevier
Background: Concurrent use of an inhaled corticosteroid (ICS) and an inhaled long-acting
β2-agonist provides better overall asthma control than the use of higher doses of ICS alone …