Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit

EM Garry, A Moss, R Rosie, A Delaney… - Molecular and Cellular …, 2003 - Elsevier
Chronic pain states arise from peripheral nerve injury and are inadequately treated with
current analgesics. Using intrathecal drug administration in a rat model of neuropathic pain …

Fibromyalgia syndrome: Canadian clinical working case definition, diagnostic and treatment protocols–a consensus document

AK Jain, BM Carruthers, MI Van De Sande… - Journal of …, 2003 - Taylor & Francis
Background: There has been a growing recognition of the need for information about
objective abnormalities in people with the fibromyalgia syndrome [FMS] and for an …

Glutamate and nitric oxide pathway in chronic daily headache: evidence from cerebrospinal fluid

V Gallai, A Alberti, B Gallai, F Coppola, A Floridi… - …, 2003 - journals.sagepub.com
A central sensitization has been advocated to explain chronic daily headache (CDH) due to
sustained peripheral sensitization of algogenic structures responsible for sustained …

Protein kinases regulate the phosphorylation of the GluR1 subunit of AMPA receptors of spinal cord in rats following noxious stimulation

L Fang, J Wu, Q Lin, WD Willis - Molecular brain research, 2003 - Elsevier
The present project was designed to investigate the role of protein kinase A (PKA) and
protein kinase C (PKC) in the regulation of phosphorylation of the GluR1 subunits of AMPA …

Activation of presynaptic NMDA receptors coupled to NaV1. 8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization

CA Parada, GG Vivancos, CH Tambeli… - Proceedings of the …, 2003 - National Acad Sciences
The present study investigated whether activation of presynaptic N-methyl-d-aspartate
(NMDA) receptors in the spinal cord produces a retrograde nociceptor sensitization …

Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats

A Hama, JW Lee, J Sagen - European journal of pharmacology, 2003 - Elsevier
Spinal cord dorsal horn N-methyl-d-aspartate (NMDA) receptors have been implicated in
central sensitization, enhanced responsiveness to peripheral stimuli following peripheral …

Increased phosphorylation of the GluR1 subunit of spinal cord α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor in rats following intradermal injection of …

L Fang, J Wu, X Zhang, Q Lin, WD Willis - Neuroscience, 2003 - Elsevier
Ionotropic glutamate receptors are ligand-gated ion channels that help mediate rapid
excitatory neurotransmission in the CNS. α-Amino-3-hydroxy-5-methyl-4-isoxazole …

Kynurenic acid enhances electroacupuncture analgesia in normal and carrageenan-injected rats

YQ Zhang, GC Ji, GC Wu, ZQ Zhao - Brain research, 2003 - Elsevier
The interaction between electroacupuncture (EA) and an intrathecally administered wide-
spectrum excitatory amino acid (EAA) receptor (s) antagonist, kynurenic acid (KYNA) on …

Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in rats

E Sato, Y Takano, Y Kuno, M Takano, I Sato - European journal of …, 2003 - Elsevier
Phosphorylation of a subunit of N-methyl-d-aspartate (NMDA) receptor by protein tyrosine
kinase (PTK) Src or Trk is known to enhance its channel activity. We examined whether a …

Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats

V Jevtovic-Todorovic, AP Meyenburg, JW Olney… - …, 2003 - Elsevier
Procyclidine and ethopropazine, widely used as anti-parkinsonian agents because of their
anti-cholinergic action, are also known to have NMDA antagonist properties. Unlike other …