Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation
The proteome contains hundreds of proteins that in theory could be excellent therapeutic
targets for the treatment of human diseases. However, many of these proteins are from …
targets for the treatment of human diseases. However, many of these proteins are from …
[HTML][HTML] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors α and β
MK Tee, I Rogatsky, C Tzagarakis-Foster… - Molecular biology of …, 2003 - Am Soc Cell Biol
Estrogens and selective estrogen receptor modulators (SERMs) interact with estrogen
receptor (ER) α and β to activate or repress gene transcription. To understand how …
receptor (ER) α and β to activate or repress gene transcription. To understand how …
Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray
KR Coser, J Chesnes, J Hur, S Ray… - Proceedings of the …, 2003 - National Acad Sciences
To obtain comprehensive information on 17β-estradiol (E2) sensitivity of genes that are
inducible or suppressible by this hormone, we designed a method that determines ligand …
inducible or suppressible by this hormone, we designed a method that determines ligand …
Chemoprevention of breast cancer and the trials of the National Surgical Adjuvant Breast and Bowel Project and others.
RE Smith, BC Good - Endocrine-related cancer, 2003 - erc.bioscientifica.com
The idea of breast cancer prevention by hormonal means stemmed from the results of
treatment trials, many of them carried out by the National Surgical Adjuvant Breast and …
treatment trials, many of them carried out by the National Surgical Adjuvant Breast and …
A review of selective estrogen receptor modulators and national surgical adjuvant breast and bowel project clinical trials
RE Smith - Seminars in oncology, 2003 - Elsevier
Over the last 20 years tamoxifen, a selective estrogen receptor modulator, has been shown
to be of clinical benefit to patients with advanced and resected hormone receptor-positive …
to be of clinical benefit to patients with advanced and resected hormone receptor-positive …