Properties, Expression and Potential Roles of Cardiac K+ Channel Accessory Subunits: MinK, MiRPs, KChIP, and KChAP

M Pourrier, G Schram, S Nattel - The Journal of membrane biology, 2003 - Springer
Over the past 10 years, cDNAs encoding a wide range of pore-forming K+-channel α-
subunits have been cloned and found to result in currents with many properties of …

Cardiac repolarization: bridging basic and clinical science

I Gussak, C Antzelevitch, SC Hammill, WK Shen… - 2003 - books.google.com
A comprehensive review of all the latest developments in cardiac electrophysiology,
focusing on both the clinical and experimental aspects of ventricular repolarization …

IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines

S Kupershmidt, ICH Yang, K Hayashi, J Wei… - The FASEB …, 2003 - Wiley Online Library
The cardiac potassium channel encoded by the human ether‐à‐go‐go related gene (HERG)
is blocked by a diverse array of common therapeutic compounds. Even transient exposure to …

[HTML][HTML] RNA Interference Reveals That EndogenousXenopus MinK-related Peptides Govern Mammalian K+ Channel Function in Oocyte Expression Studies

A Anantharam, A Lewis, G Panaghie, E Gordon… - Journal of Biological …, 2003 - ASBMB
The physiological properties of most ion channels are defined experimentally by functional
expression of their pore-forming α subunits in Xenopus laevis oocytes. Here, we cloned a …

Physiology and molecular biology of ion channels contributing to ventricular repolarization

JM Nerbonne, RS Kass - Cardiac Repolarization: Bridging Basic and …, 2003 - Springer
Ventricular action potential waveforms reflect the coordinated activity of multiple ion
channels that open, close, and inactivate on different time scales (Fig. 1). The rapid upstroke …

Method of screening for susceptibility to drug-induced cardiac arrhythmia

A George, D Roden - US Patent App. 10/260,861, 2003 - Google Patents
Isolated polynucleotide molecules, and peptides encoded by these molecules, are used in
the analysis of human cardiac potassium channel mink Subunit variants, as well as in …

Molecular Diversity of Ion Channels in the Mouse Heart: A Suitable Model for Cardiac Drug Development?

JM Nerbonne - Cardiac Drug Development Guide, 2003 - Springer
Action potential waveforms in the mammalian myocardium reflect the synchronized
activation (and inactivation) of multiple types of membrane ion channels (1) contributing …

[PDF][PDF] RNAi reveals endogenous Xenopus MiRPs govern mammalian K+ channel function in oocyte expression studies

A Anantharam, A Lewis, G Panaghie, E Gordon… - J Biol Chem, 2003 - academia.edu
RNAi reveals endogenous Xenopus MiRPs govern mammalian K+ channel function in oocyte
expression studies Arun Anantharam,* Antho Page 1 RNAi reveals endogenous Xenopus …

Animal model of atrial fibrillation and screening and therapeutic methods relating thereto

D Roden, S Kupershmidt - US Patent App. 09/877,586, 2003 - Google Patents
An animal model of atrial fibrillation and a method of identifying an animal exhibiting an
atrial fibrillation phenotype. The method includes providing an animal having a minK (−/−) …

[引用][C] and Robert S. Kass, PhD

JM Nerbonne - Cardiac Repolarization: Bridging Basic and Clinical …, 2003 - Humana Press
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