Disease model: Parkinson's disease
S Shimohama, H Sawada, Y Kitamura… - Trends in molecular …, 2003 - cell.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is primarily
characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway …
characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway …
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation
W Tatton, D Chen, R Chalmers-Redman… - Survey of …, 2003 - Elsevier
Recent studies have suggested glaucomatous loss of retinal ganglion cells and their axons
in Alzheimer's disease. Amyloid beta peptides and phosphorylated tau protein have been …
in Alzheimer's disease. Amyloid beta peptides and phosphorylated tau protein have been …
Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis
S Tada-Oikawa, Y Hiraku, M Kawanishi, S Kawanishi - Life Sciences, 2003 - Elsevier
Rotenone, an inhibitor of NADH dehydrogenase complex, is a naturally occurring
insecticide, which is capable of inducing apoptosis. Rotenone-induced apoptosis is …
insecticide, which is capable of inducing apoptosis. Rotenone-induced apoptosis is …
BAX protein-immunoreactivity in midbrain neurons of Parkinson's disease patients
JM Horowitz, DM Pastor, A Goyal, S Kar… - Brain research …, 2003 - Elsevier
Apoptosis has been implicated in the pathophysiology of Parkinson's disease (PD).
Components of signaling pathways that initiate cell death are highly concentrated in …
Components of signaling pathways that initiate cell death are highly concentrated in …
[图书][B] The role of JNK signaling and Bcl-2 in neuronal function: From apoptosis to neuron excitability
XA Figueroa-Masot - 2003 - search.proquest.com
JNKs are members of a conserved family of mitogen activated protein kinases (MAPKs) and
are important in the transmission of signals into cells that regulate their response to changes …
are important in the transmission of signals into cells that regulate their response to changes …
[图书][B] The role of the Bub1 gene in chromosomal instability and cancer progression
DV Carrion - 2003 - search.proquest.com
Colorectal cancer (CRC) is an important cause of mortality and morbidity in the world. Some
CRC tumors show chromosomal instability (CIN) and others show microsatellite instability …
CRC tumors show chromosomal instability (CIN) and others show microsatellite instability …
Mechanisms of polyglutamine expanded huntingtin induced toxicity
H Jiang - 2003 - search.proquest.com
Huntington's Disease (HD) belongs to the CAG repeat family of neurodegenerative diseases
and is characterized by the presence of an expanded polyglutamine (polyQ) repeat in the …
and is characterized by the presence of an expanded polyglutamine (polyQ) repeat in the …
[引用][C] Rationale for the use of dopamine agonists as neuroprotective agents in Parkinson's disease
AHV Schapira, CW Olanow - Annals of Neurology: Official …, 2003 - Wiley Online Library
To date, the only drug therapies of proven efficacy in the treatment of Parkinson's disease
(PD) are symptomatic. These include dopaminergic agents (L-dopa, dopamine agonists) …
(PD) are symptomatic. These include dopaminergic agents (L-dopa, dopamine agonists) …