The extracellular antagonists of the Wnt signalling pathway can be divided into two broad
classes. Both classes of molecule prevent ligand-receptor interactions, but by different …

Recent studies have postulated that distinct regulatory cascades control myogenic
differentiation in the head and the trunk. However, although the tissues and signaling …

One of the earliest manifestations of anteroposterior pattering in the developing brain is the
restricted expression of Six3 and Irx3 in the anterior and posterior forebrain, respectively …

The limb musculature arises by delamination of premyogenic cells from the lateral
dermomyotome. Initially the cells express Pax3 but, upon entering the limb bud, they switch …

Rheumatoid arthritis (RA) is a heterogeneous disease. We used cDNA microarray
technology to subclassify RA patients and disclose disease pathways in rheumatoid …

The induction of the vertebrate inner ear is a complex developmental process that has been
under investigation for decades. The traditional tools of embryology used in most of these …

To study the molecular mechanism that controls the laminar organization of the retina, we
utilized reaggregation cultures of dissociated retinal cells prepared from chicken embryos …

Human type XVIII collagen was found to be expressed as three variants, termed NC1-303,
NC1-493 and NC1-728, differing in their N-terminal non-collagenous domains (NC1). The …

The development of the skull is characterised by its dependence upon epigenetic
influences. One of the most important of these is secondary chondrogenesis, which occurs …

Wnt signal transduction has emerged as an increasingly complex pathway due to the
numerous ligands, receptors, and modulators identified in multiple developmental systems …