Viruses have evolved elegant mechanisms to evade detection and destruction by the host
immune system. One of the evasion strategies that have been adopted by large DNA viruses …

The asthmatic response is characterized by elevated production of IgE, cytokines,
chemokines, mucus hypersecretion, airway obstruction, eosinophilia, and enhanced airway …

Kaposi's sarcoma had been recognized as unique human cancer for a century before it
manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of …

An important step in the herpesvirus life cycle is the switch from latency to lytic reactivation.
In order to study the life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV), we …

Monocyte chemoattractant protein-1 (MCP-1) has been implicated in many inflammatory and
autoimmune diseases. The G-protein-coupled receptor CCR-2B is probably the most …

Chemokines constitute a large family of structurally-related small cytokines originally
identified as factors regulating the migration of leukocytes in inflammatory and immune …

The chemokine-like, secreted protein product of the U83 gene from human herpesvirus 6,
here named vCCL4, was chemically synthesized to be characterized in a complete library of …

ABSTRACT Human cytomegalovirus (CMV) US28 (and the related open reading frame
[ORF] US27) are G-protein-coupled receptor homologs believed to play a role in viral …

The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human
immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other …

Kaposi's sarcoma-associated herpesvirus (KSHV)/Human herpesvirus 8 encodes three
chemokines, which are called viral macrophage inflammatory protein (vMIP)-I,-II, and-III …