The PAX6 gene is a paradigm for our understanding of the molecular genetics of
mammalian eye development. Twelve years after its identification it is one of the most …

Homing endonucleases are highly specific catalysts of DNA strand breaks that induce the
transposition of mobile intervening sequences containing the endonuclease open reading …

PITX2 and Nkx2. 5 are two of the earliest known transcriptional markers of vertebrate heart
development. Pitx2–/–mice present with severe cardiac malformations and embryonic …

Aristaless-related genes encode a structurally defined group of homeoproteins that share a
C-terminal stretch of amino acids known as the OAR-or aristaless domain. Many aristaless …

We report the crystal structures and biophysical characterization of two stabilized mutants of
the Drosophila Engrailed homeodomain that have been engineered to minimize …

Abstract The 2.1‐Å resolution crystal structure of the MATα2 homeodomain bound to DNA
reveals the unexpected presence of two nonspecifically bound α2 homeodomains, in …

Induced fit effects in the complex of a DNA decamer with two even‐skipped transcriptional
repressor homeodomain molecules were investigated by means of molecular dynamics …

The C protein, a middle gene product of bacteriophage Mu, is the determinant of the
transition from middle to late gene expression. C activates transcription from four late gene …

The three-dimensional solution structure obtained by NMR of the A35T mutant vnd/NK-2
homeodomain bound to the vnd/NK-2 consensus 16 bp DNA sequence was determined …

Abstract Myotonic dystrophy type 1 (DM1) is the most common inherited adult muscular
disease. Clinical manifestations of DM1 include myotonia, progressive muscle weakness …