[HTML][HTML] Parkinson's disease: mechanisms and models

W Dauer, S Przedborski - Neuron, 2003 - cell.com
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

The 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease

S Przedborski, M Vila - Annals of the New York Academy of …, 2003 - Wiley Online Library
Experimental models of dopaminergic neurodegeneration play a critical role in our quest to
elucidate the cause of Parkinson's disease (PD). Despite the recent development of “genetic …

Pathogenic role of glial cells in Parkinson's disease

P Teismann, K Tieu, O Cohen, DK Choi… - … : official journal of the …, 2003 - Wiley Online Library
An erratum for this article appears in the January, 2004 issue of Movement Disorders (Mov
Disord 2004; 19: 119). Parkinson's disease (PD) is a common neurodegenerative disorder …

Nitric oxide and reactive oxygen species in Parkinson's disease

K Tieu, H Ischiropoulos, S Przedborski - IUBMB life, 2003 - Wiley Online Library
Parkinson's disease is a neurodegenerative disorder of unknown pathogenesis. Oxidative
stress has been proposed as one of several pathogenic hypotheses. Evidence for the …

Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration

T Arimoto, G Bing - Neurobiology of disease, 2003 - Elsevier
The present study was designed to examine whether expression of iNOS was involved in
LPS-induced neurodegeneration in rat substantia nigra (SN) and to study the role of NO in …

Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease

A Barzilai, E Melamed - Trends in molecular medicine, 2003 - cell.com
Parkinson's disease (PD) is a progressive neurological disease caused by selective
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) …

Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson's disease

O Eberhardt, JB Schulz - Toxicology letters, 2003 - Elsevier
The 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) model constitutes the best-
characterized toxin paradigm for Parkinson's disease, faithfully replicating most of its clinical …

Neuroprotective effects of the novel D3/D2 receptor agonist and antiparkinson agent, S32504, in vitro against 1-methyl-4-phenylpyridinium (MPP+) and in vivo against …

JN Joyce, S Presgraves, L Renish, S Borwege… - Experimental …, 2003 - Elsevier
The novel naphtoxazine derivative and preferential D3 vs D2 receptor agonist, S32504,
restores perturbed motor function in rodent and primate models of antiparkinsonian activity …

From drugs of abuse to parkinsonism: The MPTP Mouse Model of Parkinson's Disease

YS Lau, GE Meredith - Drugs of Abuse: Neurological Reviews and …, 2003 - Springer
It began with a single case of drug abuse in Maryland (1), followed by four reported cases in
California (2) in which young heroin addicts self-injected homemade “synthetic heroin” …

[图书][B] Neurochemical and immunohistochemical effects induced by the 1-methyl-4-phenylpyridinium animal model of Parkinson's disease: An in vivo microdialysis …

SB Foster - 2003 - search.proquest.com
Parkinson's disease (PD) is a neurodegenerative disorder which afflicts more than 1 million
Americans with an estimated 50,000 new diagnoses each year. 1-methyl-4-phenyl-1, 2, 3, 6 …