Fluoroquinolones, tuberculosis, and resistance
AS Ginsburg, JH Grosset, WR Bishai - The Lancet infectious …, 2003 - thelancet.com
Although the fluoroquinolones are presently used to treat tuberculosis primarily in cases
involving resistance or intolerance to first-line antituberculosis therapy, these drugs are …
involving resistance or intolerance to first-line antituberculosis therapy, these drugs are …
Fluoroquinolones: action and resistance
K Drlica, M Malik - Current topics in medicinal chemistry, 2003 - ingentaconnect.com
Fluoroquinolones trap gyrase and topoisomerase IV on DNA as ternary complexes that
block the movement of replication forks and transcription complexes. Studies with resistant …
block the movement of replication forks and transcription complexes. Studies with resistant …
Mechanisms of quinolone resistance
DC Hooper - Quinolone antimicrobial agents, 2003 - Wiley Online Library
This chapter reviews the mechanisms of quinolone resistance. Initial studies of resistant
clinical isolates of Staphylococcus aureus prior to the recognition of the role of …
clinical isolates of Staphylococcus aureus prior to the recognition of the role of …
The Rapid Development of Fluoroquinolone Resistance in M. tuberculosis
AS Ginsburg, SC Woolwine, N Hooper… - … England Journal of …, 2003 - Mass Medical Soc
To the Editor: The development of resistance in Mycobacterium tuberculosis after empirical
monotherapy could limit the role of fluoroquinolones in the treatment of tuberculosis. A 36 …
monotherapy could limit the role of fluoroquinolones in the treatment of tuberculosis. A 36 …
Fluoroquinolone-Containing Third-Line Regimen against Mycobacterium tuberculosis In Vivo
N Veziris, C Truffot-Pernot, A Aubry… - Antimicrobial agents …, 2003 - Am Soc Microbiol
The objective of the present study was to compare the activities of a third-line regimen
recommended by the World Health Organization (WHO) and two derivatives of that regimen …
recommended by the World Health Organization (WHO) and two derivatives of that regimen …
Identification of mycobacterial species by PCR sequencing of quinolone resistance-determining regions of DNA gyrase genes
JN Dauendorffer, I Guillemin, A Aubry… - Journal of clinical …, 2003 - Am Soc Microbiol
The determination of the amino acid sequence of quinolone resistance-determining regions
(QRDRs) in the A and B subunits of DNA gyrase is the molecular test for the detection of …
(QRDRs) in the A and B subunits of DNA gyrase is the molecular test for the detection of …
Fármacos con actividad frente a Mycobacterium tuberculosis
P Coll - Enfermedades infecciosas y microbiología clínica, 2003 - Elsevier
El tratamiento de Mycobacterium tuberculosis ha de ser prolongado, ya que existen
poblaciones de bacilos diferentes en cuanto a su actividad metabólica, y asociar varios …
poblaciones de bacilos diferentes en cuanto a su actividad metabólica, y asociar varios …
Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using Touch-Down (TD) PCR
SK Kim, SB Lee, TJ Kang… - FEMS Immunology & …, 2003 - academic.oup.com
The lack of methods to identify Mycobacterium leprae with the resistance against multi-drugs
quickly and specifically has hindered effective chemotherapy against M. leprae infection. To …
quickly and specifically has hindered effective chemotherapy against M. leprae infection. To …
利用质粒指纹图谱法对大肠杆菌耐药质粒遗传特性的研究
郑鑫， 刘清河， 刘晓华， 王锡香 - 吉林农业大学学报, 2003 - cqvip.com
为研究鸡源大肠杆菌耐药性及耐药的生物学特性, 选用30 株来自不同地区的鸡源大肠杆菌,
在药敏试验的基础上, 对耐药菌质粒进行了指纹图谱分析. 结果表明: 30 株鸡源大肠杆菌对氨苄 …
在药敏试验的基础上, 对耐药菌质粒进行了指纹图谱分析. 结果表明: 30 株鸡源大肠杆菌对氨苄 …
嗜水气单胞菌喹诺酮类药物抗性决定区基因片段的克隆与突变分析
卢强， 郑伟， 李莲瑞， 刘明远， 于海彬 - 吉林农业大学学报, 2003 - cqvip.com
将分离到的4 株对环丙沙星, 诺氟沙星和氧氟沙星等喹诺酮类药物耐药的嗜水气单胞菌, 2
株敏感菌, 进行旋转酶基因A 亚单位(gyrA) 喹诺酮抗性决定区基因(QRDR) PCR 扩增 …
株敏感菌, 进行旋转酶基因A 亚单位(gyrA) 喹诺酮抗性决定区基因(QRDR) PCR 扩增 …