Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of
the allergic response. Initial studies in animal models of disease provided compelling …

Hundreds of genetic association studies on asthma-related phenotypes have been
conducted in different populations. To date, variants in 64 genes have been reported to be …

BACKGROUND: Asthma is a complex genetic disease characterized by reversible
intermittent airway obstruction and respiratory symptoms primarily caused by acute and …

The association of variants of genes encoding interleukin (IL)–4 and the IL-4 receptor α
chain (IL-4Rα) with respiratory syncytial virus (RSV) bronchiolitis was examined in …

We studied a cohort containing 368 children at high risk of developing atopy and atopic
disorders and 540 parents of those children to investigate whether the IL13 Arg130Gln and …

Several studies indicate genetic involvement of Th2 cytokines in allergic diseases.
Interleukin (IL)‐13 has been mapped to the cytokine cluster on chromosome 5q31–33 …

Background: Increased total serum IgE levels are a common characteristic of atopic
disorders. Six potentially functional variants, including C-590T in the IL4 gene, C-1055T and …

Allergic rhinitis is a major public health problem and has seen its prevalence increase
during the past few decades. Interleukin 13 (IL-13) has been implicated in the pathogenesis …

Two interleukin 13 receptors (IL-13Rs) have been identified as IL-13Rα1 and IL-13Rα2. IL-
13Rα1 is composed of a heterodimer consisting of IL-13Rα1 and IL-4 receptor α (IL-4Rα) as …

Allergic diseases are most likely due to interactions between genetic and environmental
factors. While many of the environmental components have been studied for years, only …