HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands

S Kikuchi, T Fukazawa, M Niino, I Yabe, R Miyagishi… - Neurology, 2003 - AAN Enterprises
Background: Oligoclonal IgG bands (OCB) are present in most patients with MS in Western
countries; however, in Japanese MS patients, the OCB-positive rate is not as high. A …

Multiple sclerosis in Finland: incidence trends and differences in relapsing remitting and primary progressive disease courses

ML Sumelahti, PJ Tienari, M Hakama… - Journal of Neurology …, 2003 - jnnp.bmj.com
Objective: To compare the secular trends and geographical differences in the incidence of
relapsing-remitting (RRMS) and primary progressive multiple sclerosis (PPMS) in Finland …

HLA genotypes and disease severity assessed by magnetic resonance imaging findings in patients with multiple sclerosis

R Zivadinov, L Uxa, T Zacchi, D Nasuelli, M Ukmar… - Journal of …, 2003 - Springer
The objective of the study was to examine the relationship between HLA genotypes and
disease severity as measured by brain MRI quantitative markers of demyelinating and …

A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

M Liguori, S Sawcer, E Setakis, A Compston… - Journal of …, 2003 - Elsevier
We have systematically screened the genome for evidence of linkage disequilibrium (LD)
with multiple sclerosis (MS) by typing 6000 microsatellite markers in case–control and family …

Searching for needles in haystacks—the genetics of multiple sclerosis and other common neurological diseases

AE Hensiek, SJ Sawcer, DAS Compston - Brain research bulletin, 2003 - Elsevier
Recent years have witnessed considerable advances in our understanding of monogenic
neurodegenerative diseases, such as hereditary motor sensory neuropathy and …

High frequency of psoriasis in relatives is associated with early onset in an Italian multiple sclerosis cohort

P Annunziata, P Morana, A Giorgio… - Acta neurologica …, 2003 - Wiley Online Library
Objectives–An exploratory study has been carried out to assess the association of
autoimmune diseases in multiple sclerosis (MS) families with clinical features and disability …

Paradoxical effects of arthritis‐regulating chromosome 4 regions on myelin oligodendrocyte glycoprotein‐induced encephalomyelitis in congenic rats

K Becanovic, L Bäckdahl, E Wallström… - European journal of …, 2003 - Wiley Online Library
Immunoregulatory gene loci in different organ‐specific inflammatory diseases often co‐
localize. We here studied myelin oligodendrocyte glycoprotein (MOG)‐induced EAE in rat …

A genome-wide screen for association in Hungarian multiple sclerosis

C Rajda, K Bencsik, E Seres, A Jonasdottir… - Journal of …, 2003 - Elsevier
Although the pathogenesis of multiple sclerosis (MS) is not fully understood, substantial
evidence points to the involvement of genetic factors. We report on a genome-wide screen …

多发性硬化与遗传研究进展

王康, 王国相 - 国外医学: 遗传学分册, 2003 - cqvip.com
多发性硬化与遗传研究进展-[维普官方网站]-www.cqvip.com-维普网  我的维普 购物车 充值 客服
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多发性硬化的基因研究

周文斌, 周颖, 肖波 - 国外医学: 神经病学. 神经外科学分册, 2003 - cqvip.com
多发性硬化(MS) 是一种中枢神经系统慢性炎性脱髓鞘疾病. 研究资料表明遗传因素和环境因素
共同作用导致该病的发生. MS 的遗传易感性是由多个微效基因共同决定的. MHC …