▪ Abstract Transposons are mobile genetic elements that can relocate from one genomic
location to another. As well as modulating gene expression and contributing to genome …

Abstract The Sleeping Beauty (SB) transposon system, derived from teleost fish sequences,
is extremely effective at delivering DNA to vertebrate genomes, including those of humans …

We used the Tc1/mariner family transposable element Sleeping Beauty (SB) for
transgenesis and long-term expression studies in the zebrafish (Danio rerio), a popular …

Transposon-based vectors represent promising new tools for chromosomal transgene
insertion and establishment of persistent gene expression in vivo. Here, we report the …

Sleeping Beauty is a synthetic “cut-and-paste” transposon of the Tc1/mariner class. The
Sleeping Beauty transposase (SB) was constructed on the basis of a consensus sequence …

Gene transfer to the lung could provide important new treatments for chronic and acquired
lung diseases such as cystic fibrosis, α1-antitrypsin deficiency, emphysema, and cancer …

Herein, we report that the DNA-dependent protein kinase (DNA-PK) regulates the DNA
damage introduced during Sleeping Beauty (SB) element excision and reinsertion in …

Transposable elements, or transposons, have played a significant role in the history of
biological research. They have had a major influence on the structure of genomes during …

Phage integrases catalyze site-specific, unidirectional recombination between two short att
recognition sites. Recombination results in integration when the att sites are present on two …

Since the beginning of time, humans have known how to distinguish living organisms from
inanimate objects. Cro-Magnon people and their descendants were no doubt aware that …