ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

Hypoglycaemic agents such as sulphonylureas and the newer group of" glinides" stimulate
insulin secretion by closing ATP-sensitive potassium (K ATP) channels in pancreatic beta …

Biologic membranes are not simply inert physical barriers, but complex and dynamic
environments that affect membrane protein structure and function. Residing within these …

Blood glucose levels are sensed and controlled by the release of hormones from the islets of
Langerhans in the pancreas. The β-cell, the insulin-secreting cell in the islet, can detect …

Inwardly rectifying K+ (Kir) channels have a wide range of functions including the control of
neuronal signalling, heart rate, blood flow and insulin release. Because of the physiological …

Abstract Phosphatidylinositol‐4, 5‐bisphosphate (PIP 2) is a major signaling molecule
implicated in the regulation of various ion transporters and channels. Here we show that PIP …

Phosphoinositides are critical regulators of ion channel and transporter activity. Defects in
interactions of i nwardly r ectifying potassium (Kir) channels with phosphoinositides lead to …

ATP-sensitive K+ channels (KATP) couple intermediary metabolism to cellular activity, and
may play a role in the autoregulation of vascular tones. Such a regulation requires cellular …

Although ischemic preconditioning induces bioenergetic tolerance and thereby remodels
energy metabolism that is crucial for postischemic recovery of the heart, the molecular …

Based initially on their prominence in the squid giant axon, their useful pharmacology, and
subsequently on being the first cloned K channels, voltage-gated K (Kv) channels have …