Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal …
V Simonneaux, C Ribelayga - Pharmacological reviews, 2003 - ASPET
Melatonin, the major hormone produced by the pineal gland, displays characteristic daily
and seasonal patterns of secretion. These robust and predictable rhythms in circulating …
and seasonal patterns of secretion. These robust and predictable rhythms in circulating …
[PDF][PDF] Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
This brief resume enumerates the multiple actions of melatonin as an antioxidant. This
indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other …
indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other …
[PDF][PDF] Molecular pharmacology, regulation and function of mammalian melatonin receptors
ML Dubocovich, MA Rivera-Bermudez, MJ Gerdin… - Front …, 2003 - article.imrpress.com
Introduction 3. Melatonin receptors 3.1. MT1 and MT2 melatonin receptors 3.1. 1. Molecular
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …
Melatonin and cell death: differential actions on apoptosis in normal and cancer cells
Melatonin is a natural compound synthesized by a variety of organs. It has been shown to
function as a cell-protective agent. Since 1994, when the first paper was published …
function as a cell-protective agent. Since 1994, when the first paper was published …
Functional melatonin receptors in rat ovaries at various stages of the estrous cycle
JM Soares, MI Masana, Ç Erşahin… - Journal of Pharmacology …, 2003 - ASPET
This study investigated the receptor mechanism (s) by which the hormone melatonin directly
affects ovarian function. Expression of MT1 and MT2 melatonin receptor mRNA was …
affects ovarian function. Expression of MT1 and MT2 melatonin receptor mRNA was …
Melatonin and mammary cancer: a short review.
S Cos, R Fern, MD Mediavilla - Endocrine-related cancer, 2003 - erc.bioscientifica.com
Melatonin is an indolic hormone produced mainly by the pineal gland. The former
hypothesis of its possible role in mammary cancer development was based on the evidence …
hypothesis of its possible role in mammary cancer development was based on the evidence …
Melatonin reduces lipid peroxidation and nitric oxide during irradiation‐induced oxidative injury in the rat liver
S Taysi, M Koc, ME Büyükokuroğlu… - Journal of pineal …, 2003 - Wiley Online Library
Radiation therapy is a popular and useful tool in the treatment of cancer. Melatonin
participates in the regulation of a number of important physiological and pathological …
participates in the regulation of a number of important physiological and pathological …
Melatonin: detoxification of oxygen and nitrogen-based toxic reactants
In the last decade, melatonin has been found to be highly protective against damage to
macromolecules resulting from oxygen and nitrogen-based reactants. Considering this …
macromolecules resulting from oxygen and nitrogen-based reactants. Considering this …
The role of pineal gland in breast cancer development
VN Anisimov - Critical reviews in oncology/hematology, 2003 - Elsevier
The role of the modulation of the pineal gland function in development of breast cancer is
discussed in this review. An inhibition of the pineal function with pinealectomy or with the …
discussed in this review. An inhibition of the pineal function with pinealectomy or with the …
Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice
Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells
significantly enhances the response of these cells to the growth-inhibitory actions of …
significantly enhances the response of these cells to the growth-inhibitory actions of …