'Ready made'virulence and 'dual use'virulence factors in pathogenic environmental fungi—the Cryptococcus neoformans paradigm

A Casadevall, JN Steenbergen… - Current Opinion in …, 2003 - Elsevier
Environmental pathogenic fungi present a paradox in that they are virulent in animals
without requiring animal hosts for replication or survival, a phenomenon we call 'ready …

[HTML][HTML] The origin and maintenance of virulence for the human pathogenic fungus Cryptococcus neoformans

JN Steenbergen, A Casadevall - Microbes and infection, 2003 - Elsevier
The origin of virulence in environmental fungi that have no requirement for animal hosts in
their life cycle is enigmatic. Cryptococcus neoformans is a human pathogenic fungus with …

Superoxide Dismutase Influences the Virulence of Cryptococcus neoformans by Affecting Growth within Macrophages

GM Cox, TS Harrison, HC McDade… - Infection and …, 2003 - Am Soc Microbiol
Superoxide dismutase (SOD) is an enzyme that converts superoxide radicals into hydrogen
peroxide and molecular oxygen and has been shown to contribute to the virulence of many …

Cryptococcus neoformans Virulence Is Enhanced after Growth in the Genetically Malleable Host Dictyostelium discoideum

JN Steenbergen, JD Nosanchuk… - Infection and …, 2003 - Am Soc Microbiol
Cryptococcus neoformans is an encapsulated, environmental fungus that can cause life-
threatening meningitis. Pathogenicity of C. neoformans for macrophages and vertebrate …

Role of Alternative Oxidase Gene in Pathogenesis of Cryptococcus neoformans

S Akhter, HC McDade, JM Gorlach… - Infection and …, 2003 - Am Soc Microbiol
We identified a homologue of the alternative oxidase gene in a screen to identify genes that
are preferentially transcribed in response to a shift to 37° C in the human-pathogenic yeast …

Characterization of Cu,Zn superoxide dismutase (SOD1) gene knock‐out mutant of Cryptococcus neoformans var. gattii: role in biology and virulence

SD Narasipura, JG Ault, MJ Behr… - Molecular …, 2003 - Wiley Online Library
The pathogenic yeast Cryptococcus neoformans (Cn) var. gattii causes meningoencephalitis
in healthy individuals, unlike the better known Cn varieties grubii and neoformans, which are …

A MAP kinase cascade composed of cell type specific and non‐specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans

RC Davidson, CB Nichols, GM Cox… - Molecular …, 2003 - Wiley Online Library
Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle in
which the α allele of the mating type locus is linked to virulence and haploid differentiation …

[HTML][HTML] An α-1, 3-mannosyltransferase of Cryptococcus neoformans

U Sommer, H Liu, TL Doering - Journal of Biological Chemistry, 2003 - ASBMB
Cryptococcus neoformans is a pathogenic fungus, distinguished by an elaborate
polysaccharide capsule that is essential for its virulence. As part of an effort to understand …

Sequence length required for homologous recombination in Cryptococcus neoformans

RT Nelson, BA Pryor, JK Lodge - Fungal Genetics and Biology, 2003 - Elsevier
Cryptococcosis is a major threat to immunocompromised individuals. Isolates of
Cryptococcus neoformans var. grubii and var. neoformans are responsible for most of the …

Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment

DL Toffaletti, M Del Poeta, TH Rude… - …, 2003 - microbiologyresearch.org
In the study of differential gene expression of Cryptococcus neoformans, a transcript of
COX1 (cytochrome oxidase c subunit 1) was identified in a serotype A strain. The transcript …