Chromatin is the complex of DNA and proteins in which the genetic material is packaged
inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts …

In the present genomics era, powerful reverse-genetic strategies are needed to elucidate
gene and protein function in the context of a whole organism. However, most current …

We attempted to answer two central questions about epigenetic silencing of the tumor
suppressor gene p16 INK4a in this study:(1) whether the maintenance of associated histone …

Covalent modifications of the histone proteins have well-known roles in gene expression.
Experiments reported during the past year have extended this paradigm to include roles for …

The extent and pattern of histone post-translational modifications is a key determinant
dictating the structure of chromatin. We employed mass spectrometry to map the post …

The potential anticancer activities of histone deacetylase (HDAC) inhibitors and DNA
methyltransferase (DNMT) inhibitors have been extensively studied in recent years. HDAC …

Epigenetic regulation is essential for temporal, tissue-specific and parent-of-origin–
dependent gene expression. It has recently been found that the mouse Polycomb group …

How T cells regulate interleukin 4 (IL-4) expression is not completely understood. We show
here that single-positive thymocytes express IL-4, but attenuate GATA-3 expression, recruit …

Two classes of functional DNA (cytosine-5) methyltransferases have been discovered in
mammals to date. One class methylates the unmodified DNA and is designated as the de …

CpG‐island hypermethylation of gene promoters is a frequent mechanism for gene
inactivation in tumors. Many neuroblastomas have hypermethylation and down‐regulation of …