Statin effects beyond lipid lowering—are they clinically relevant?

PO Bonetti, LO Lerman, C Napoli… - European heart …, 2003 - academic.oup.com
Currently, five different statins (simvastatin, pravastatin, lovastatin, fluvastatin, and
atorvastatin) are approved for treatment of hypercholesterolemia in humans and two new …

[HTML][HTML] Roles of matrix metalloproteinases in tumor metastasis and angiogenesis

SO Yoon, SJ Park, CH Yun, AS Chung - BMB Reports, 2003 - koreascience.kr
Matrix metalloproteinases (MMPs), zinc dependent proteolytic enzymes, cleave extracellular
matrix (ECM: collagen, laminin, firbronectin, etc) as well as non-matrix substrates (growth …

Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition

A Das, PG McGuire - Progress in retinal and eye research, 2003 - Elsevier
Retinal angiogenesis and choroidal angiogenesis are major causes of vision loss, and the
pathogenesis of this angiogenesis process is still uncertain. However, several key steps of …

Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1‐MMP, MMP‐2 and MMP‐9 in human glioblastomas

C Munaut, A Noël, O Hougrand… - … journal of cancer, 2003 - Wiley Online Library
Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central
nervous system neoplasms and it is expressed in 64–95% of glioblastomas (GBMs). Tumour …

Flavonoids inhibit VEGF/bFGF‐induced angiogenesis in vitro by inhibiting the matrix‐degrading proteases

MH Kim - Journal of cellular biochemistry, 2003 - Wiley Online Library
Flavonoids have been proposed to act as chemopreventive agents in numerous
epidemiological studies and have been shown to inhibit angiogenesis and proliferation of …

Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis

RT Aimes, A Zijlstra, JD Hooper… - Thrombosis and …, 2003 - thieme-connect.com
Many serine proteases play important regulatory roles in complex biological systems, but
only a few have been linked directly with capillary morphogenesis and angiogenesis. Here …

Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM

RA Brekken, P Puolakkainen… - The Journal of …, 2003 - Am Soc Clin Investig
SPARC, a 32-kDa glycoprotein, participates in the regulation of morphogenesis and cellular
differentiation through its modulation of cell-matrix interactions. Major functions defined for …

MMP‐2 and MMP‐9 synergize in promoting choroidal neovascularization

V Lambert, B Wielockx, C Munaut, C Galopin… - The FASEB …, 2003 - Wiley Online Library
ABSTRACT Matrix metalloproteinase 2 (MMP‐2) and MMP‐9 are increased in human
choroidal neovascularization (CNV) occurring during the exudative most aggressive form of …

Vascular integrins: pleiotropic adhesion and signaling molecules in vascular homeostasis and angiogenesis

C Rüegg, A Mariotti - Cellular and Molecular Life Sciences CMLS, 2003 - Springer
New blood vessel formation, a process referred to as angiogenesis, is essential for
embryonic development and for many physiological and pathological processes during …

Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases

B Heissig, K Hattori, M Friedrich, S Rafii… - Current opinion in …, 2003 - journals.lww.com
Endothelial cell invasion is an essential event during angiogenesis (the formation of new
blood vessels). This process involves the degradation of the extracellular matrix, the …