Currently, five different statins (simvastatin, pravastatin, lovastatin, fluvastatin, and
atorvastatin) are approved for treatment of hypercholesterolemia in humans and two new …

Matrix metalloproteinases (MMPs), zinc dependent proteolytic enzymes, cleave extracellular
matrix (ECM: collagen, laminin, firbronectin, etc) as well as non-matrix substrates (growth …

Retinal angiogenesis and choroidal angiogenesis are major causes of vision loss, and the
pathogenesis of this angiogenesis process is still uncertain. However, several key steps of …

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central
nervous system neoplasms and it is expressed in 64–95% of glioblastomas (GBMs). Tumour …

Flavonoids have been proposed to act as chemopreventive agents in numerous
epidemiological studies and have been shown to inhibit angiogenesis and proliferation of …

Many serine proteases play important regulatory roles in complex biological systems, but
only a few have been linked directly with capillary morphogenesis and angiogenesis. Here …

SPARC, a 32-kDa glycoprotein, participates in the regulation of morphogenesis and cellular
differentiation through its modulation of cell-matrix interactions. Major functions defined for …

ABSTRACT Matrix metalloproteinase 2 (MMP‐2) and MMP‐9 are increased in human
choroidal neovascularization (CNV) occurring during the exudative most aggressive form of …

New blood vessel formation, a process referred to as angiogenesis, is essential for
embryonic development and for many physiological and pathological processes during …

Endothelial cell invasion is an essential event during angiogenesis (the formation of new
blood vessels). This process involves the degradation of the extracellular matrix, the …