This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …

Maintaining the integrity of the gastrointestinal tract, despite the continual presence of
microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of …

We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …

The DNA methyltransferases, Dnmts, are the enzymes responsible for methylating DNA in
mammals, which leads to gene silencing. Repression by DNA methylation is mediated partly …

The biochemistry of aging is complex, with biologically significant changes occurring in
proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA …

DNA methylation occurs in bacteria, fungi, plants and animals, however its role varies widely
among different organisms. Even within animal genomes, methylation patterns vary …

The identification and characterization of molecular mechanisms utilized by cells to mediate
transcriptional repression at methylated loci are fundamental to understanding the biological …

Purpose: Three genes, namely DNA methyltransferase (DNMT) 1, DNMT3A, and DNMT3B,
coding for DNMTs that affect promoter methylation status are thought to play an important …

During mammalian cell division, DNA methylation patterns are transferred accurately to the
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …

Antigen and cytokine receptor signals act in synergy to direct the differentiation of CD4+ T
cells. These signals initiate reciprocal activation and silencing of the interferon-γ (IFN-γ) and …