A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function

N Jones, SH Chen, C Sturk, Z Master… - … and cellular biology, 2003 - Am Soc Microbiol
Tie2/Tek is an endothelial cell receptor tyrosine kinase that induces signal transduction
pathways involved in cell migration upon angiopoietin-1 (Ang1) stimulation. To address the …

Molecular mechanisms in lymphangiogenesis: model systems and implications in human disease

H Kim, DJ Dumont - Clinical genetics, 2003 - Wiley Online Library
The basic science and development of therapies targeting the blood vascular system has
enjoyed much focus due to the knowledge of the molecular mechanisms behind its …

Transcriptional and post‐translation regulation of the Tiel receptor by fluid shear stress changes in vascular endothelial cells

L Chen-Konak, Y Guetta-Shubin, H Yahav… - The FASEB …, 2003 - Wiley Online Library
The interaction between the vascular endothelium and hemodynamic forces (and more
specifically, fluid shear stress), induced by the flow of blood, plays a major role in vascular …

[PDF][PDF] Neoangiogenesis in human astrocytomas: expression and functional role of angiopoietins and their cognate receptors

G Zadeh, A Guha - Front Biosci, 2003 - researchgate.net
Introduction 2.1. Tumor angiogenesis 2.1. Astrocytoma angiogenesis 3. Angiopoietins and
tie receptors 3.1. Tie2 receptor 3.2. Angiopoietins 3.3. Biological role of Angiopoietins in …

Measurement of the soluble angiopoietin receptor tie‐2 in patients with coronary artery disease: Development and application of an immunoassay

NAY Chung, AJ Makin, GYH Lip - European journal of clinical …, 2003 - Wiley Online Library
Background The angiopoietin family has emerged as a group of crucial growth factors to
normal angiogenesis. They are essential to the development of the mature vessel wall and …

Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data

A Wallqvist, AA Rabow, RH Shoemaker… - …, 2003 - academic.oup.com
Motivation: Data mining tools are proposed to establish mechanistic connections between
chemotypes and specific cellular functions. Drawing on a previous study that classified the …

[PDF][PDF] Vascular endothelial growth factors and the Bmx tyrosine kinase in the regulation of angiogenesis and lymphangiogenesis

K Paavonen - 2003 - core.ac.uk
Neoplastic cells are characterized by distinct alterations in the genome that are associated
with characteristic changes in cell physiology: self-sufficiency in growth signals, insensitivity …

Regulation von vasoaktiven Peptiden und Mediatoren der Gefäßbildung durch kardiovaskuläre Risikofaktoren und biomechanische Kräfte

W Göttsch - 2003 - nbn-resolving.org
Die Regulation von vasoaktiven Peptiden durch kardiovaskuläre Risikofaktoren wurde im
ersten Teil der Arbeit untersucht. Dabei lag der Schwerpunkt in der Aufklärung von …

[引用][C] VEGF and the Angiopoietins Activate Numerous Signaling Pathways that Govern Angiogenesis

C Daly, J Holash - Handbook of Cell Signaling, 2003 - Elsevier