Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease
SO Bachurin - Medicinal Research Reviews, 2003 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia, which is characterised by
progressive deterioration of memory and higher cortical functions that ultimately result in …
progressive deterioration of memory and higher cortical functions that ultimately result in …
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors
M Samochocki, A Höffle, A Fehrenbacher… - … of Pharmacology and …, 2003 - ASPET
Galantamine (Reminyl), an approved treatment for Alzheimer's disease (AD), is a potent
allosteric potentiating ligand (APL) of human α3β4, α4β2, and α6β4 nicotinic receptors …
allosteric potentiating ligand (APL) of human α3β4, α4β2, and α6β4 nicotinic receptors …
Nicotinic receptors and Alzheimer's disease
M Bourin, N Ripoll, E Dailly - Current medical research and …, 2003 - Taylor & Francis
Nicotinic receptors (NRs) belong to the group of polymeric receptors of the cell membrane
and are key elements of cholinergic transmission. Numerous subtypes of NRs exist, with the …
and are key elements of cholinergic transmission. Numerous subtypes of NRs exist, with the …
Alzheimer's disease is associated with a selective increase in α7 nicotinic acetylcholine receptor immunoreactivity in astrocytes
T Teaktong, A Graham, J Court, R Perry, E Jaros… - Glia, 2003 - Wiley Online Library
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of
dementia in the elderly associated with cholinergic dysfunction, including reductions in …
dementia in the elderly associated with cholinergic dysfunction, including reductions in …
Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia
CM Martin-Ruiz, VH Haroutunian, P Long, AH Young… - Biological …, 2003 - Elsevier
BACKGROUND: The etiology of dementia that occurs in patients with schizophrenia is not
well understood. Nicotinic acetylcholine receptors have been implicated in cognitive …
well understood. Nicotinic acetylcholine receptors have been implicated in cognitive …
Differential nicotinic acetylcholine receptor subunit expression in the human hippocampus
AJ Graham, MA Ray, EK Perry, E Jaros… - Journal of chemical …, 2003 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels
composed of α and β subunits with specific structural, functional and pharmacological …
composed of α and β subunits with specific structural, functional and pharmacological …
[引用][C] NEUROTRANSMISIÓN, SEÑALES DE CALCIO Y ENFERMEDAD DE ALZHEIMER
M Aldea, M Sobrado, J Fuentealba, G Arroyo - FRONTERAS EN LA ENFERMEDAD DE …