[HTML][HTML] Activation of autoreactive B cells by CpG dsDNA
The proliferative response of autoreactive rheumatoid factor (RF) B cells to mammalian
chromatin-containing immune complexes (ICs) results from the sequential engagement of …
chromatin-containing immune complexes (ICs) results from the sequential engagement of …
The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models
ML Fields, J Erikson - Current opinion in immunology, 2003 - Elsevier
Several advances have been made regarding the regulation of lupus-associated
autoantibodies, including the identification of factors that lead to their production in …
autoantibodies, including the identification of factors that lead to their production in …
Positive selection of anti–thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development
K Hayakawa, M Asano, SA Shinton, M Gui… - The Journal of …, 2003 - rupress.org
A natural serum autoantibody specific for the Thy-1 glycoprotein (anti–Thy-1 autoantibody
[ATA]) is produced by B-1 cells that are positively selected by self-antigen. Here, using …
[ATA]) is produced by B-1 cells that are positively selected by self-antigen. Here, using …
The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells
Systemic autoimmune disease is frequently characterized by the production of
autoantibodies against widely expressed intracellular self-antigens, whereas B cell …
autoantibodies against widely expressed intracellular self-antigens, whereas B cell …
Activation of Rheumatoid Factor (RF) B Cells and Somatic Hypermutation Outside of Germinal Centers in Autoimmune‐Prone MRL/lpr Mice
MJ Shlomchik, CW Euler… - Annals of the New …, 2003 - Wiley Online Library
Two critical questions need to be answered concerning the origins of autoreactive B cells in
autoimmunity. First, how are autoreactive B cells regulated in normal situations? Second …
autoimmunity. First, how are autoreactive B cells regulated in normal situations? Second …
The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis
P Wernhoff, P Olofsson… - Arthritis & Rheumatism …, 2003 - Wiley Online Library
Objective To investigate the genetic regulation of rheumatoid factor (RF) in a rat model of
rheumatoid arthritis, in order to gain understanding of the enigmatic role of RF in the …
rheumatoid arthritis, in order to gain understanding of the enigmatic role of RF in the …
Tolerance through indifference: autoreactive B cells to the nuclear antigen La show no evidence of tolerance in a transgenic model
BD Aplin, CL Keech, AL de Kauwe… - The Journal of …, 2003 - journals.aai.org
Systemic autoimmune diseases are characterized by the production of high titer
autoantibodies specific for ubiquitous nuclear self-Ags such as DNA, Sm, and La (SS-B), so …
autoantibodies specific for ubiquitous nuclear self-Ags such as DNA, Sm, and La (SS-B), so …