Narcotic analgesics
JV Aldrich, SC Vigil‐Cruz - Burger's Medicinal Chemistry and …, 2003 - Wiley Online Library
Narcotic analgesics such as morphine have been the mainstay for the treatment of severe
pain, although these drugs are associated with serious adverse effects, most notably …
pain, although these drugs are associated with serious adverse effects, most notably …
Utilizing functional genomics to identify new pain treatments: the example of nociceptin
JC Meunier - American Journal of Pharmacogenomics, 2003 - Springer
Nociceptin/orphanin FQ (noc/oFQ) is the first novel bioactive substance to have been
discovered by the implementation of a functional genomics/reverse pharmacology …
discovered by the implementation of a functional genomics/reverse pharmacology …
[3H]-nociceptin ligand-binding and nociceptin opioid receptor mrna expression in the human brain
A Berthele, S Platzer, D Dworzak, J Schadrack… - Neuroscience, 2003 - Elsevier
Following the cloning of the novel nociceptin opioid receptor (NOP1) and the identification of
its endogenous ligand orphanin FQ/nociceptin the distribution and functional role of the …
its endogenous ligand orphanin FQ/nociceptin the distribution and functional role of the …
Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5‐hydroxytryptamine and noradrenaline release in the rat neocortex
M Marti, S Stocchi, F Paganini, F Mela… - British journal of …, 2003 - Wiley Online Library
The pharmacological profiles of presynaptic nociceptin/orphanin FQ (N/OFQ) peptide
receptors (NOP) modulating 5‐hydroxytryptamine (5‐HT) and noradrenaline (NE) release in …
receptors (NOP) modulating 5‐hydroxytryptamine (5‐HT) and noradrenaline (NE) release in …
Opioid receptor ligands
CR McCurdy, TE Prisinzano - Burger's Medicinal Chemistry …, 2003 - Wiley Online Library
Opioid agonists, exemplified by morphine, have been the most prescribed class of drugs for
the management of moderate to severe pain for many years. These drugs have significant …
the management of moderate to severe pain for many years. These drugs have significant …
Distribution of ORL-1 receptor binding and receptor-activated G-proteins in rat forebrain and their experimental localization in anterior cingulate cortex
LJ Sim-Selley, LJ Vogt, SR Childers, BA Vogt - Neuropharmacology, 2003 - Elsevier
Opioid receptor-like (ORL-1) receptors and ORL-1-activated G-proteins are found in high
levels in the forebrain, particularly cingulate cortex, an area involved in processing of …
levels in the forebrain, particularly cingulate cortex, an area involved in processing of …
Центральные эффекты лигандов ORL1 рецепторов
ЛН Маслов, ЮБ Лишманов, Д Кало… - Экспериментальная и …, 2003 - ekf.folium.ru
В 1994 г. исследователи одновременно в нескольких лабораториях обнаружили и
клонировали ORL1rреr цептор (opioid receptor like, опиоидrподобный рецепr тор) …
клонировали ORL1rреr цептор (opioid receptor like, опиоидrподобный рецепr тор) …
Периферические эффекты лигандов ORL1 рецепторов
ЛН Маслов, ЮБ Лишманов, Д Кало, Л Ма… - Экспериментальная и …, 2003 - ekf.folium.ru
В 1994 г. одновременно и независимо друг от друга несколько исследовательских
коллективов клонироваr ли до того времени неизвестный рецептор, названный …
коллективов клонироваr ли до того времени неизвестный рецептор, названный …
孤啡肽OFQ 的溶液构象研究
何发虎， 张琪， 石喜豪， 崔大敷， 吴厚铭 - 化学学报, 2003 - sioc-journal.cn
摘要应用近代NMR 波谱技术对孤啡肤0 问及其片段. F 也17 的溶液结构进行了比较研究,
测定了孤啡肤OFQ 和片段. FQs _17 在H20 和πElH20 两种溶剂条件下的2D-DQF-COSY, 2D …
测定了孤啡肤OFQ 和片段. FQs _17 在H20 和πElH20 两种溶剂条件下的2D-DQF-COSY, 2D …
Sodium ions and GTP decrease the potency of [Nphe1] N/OFQ (1–13) NH2 in blocking nociceptin/orphanin FQ receptors coupled to cyclic AMP in N1E-115 …
MC Olianas, P Onali - Life sciences, 2003 - Elsevier
The pseudopeptide [Nphe1] N/OFQ (1–13) NH2 (Nphe) has been shown to act as a pure,
selective and competitive antagonist of nociceptin/orphanin FQ (N/OFQ) receptors in …
selective and competitive antagonist of nociceptin/orphanin FQ (N/OFQ) receptors in …