[HTML][HTML] Physiological and pathophysiological roles of ATP-sensitive K+ channels

S Seino, T Miki - Progress in biophysics and molecular biology, 2003 - Elsevier
ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart

T Miura, T Miki - Current Vascular Pharmacology, 2003 - ingentaconnect.com
Different types of ATP-sensitive K+ (KATP) channels have been identified in cardiomyocytes,
vascular smooth muscle cells, pancreatic β-cells, neurons and mitochondria. Years before …

Contribution of endothelin and its receptors to the regulation of vascular tone during exercise is different in the systemic, coronary and pulmonary circulation

D Merkus, B Houweling, A Mirza… - Cardiovascular …, 2003 - academic.oup.com
Objectives: Exercise-induced vasodilation is thought to be mediated through various
vasodilator substances, but blunting the influence of vasoconstrictors such as ET may also …

Coronary blood flow regulation in exercising swine involves parallel rather than redundant vasodilator pathways

D Merkus, DB Haitsma, TY Fung… - American Journal …, 2003 - journals.physiology.org
In dogs, only combined blockade of vasodilator pathways [via adenosine receptors, nitric
oxide synthase (NOS) and ATP-sensitive K+ (KATP) channels] results in impairment of …

Coronary blood flow regulation in the prediabetic metabolic syndrome

S Setty, W Sun, JD Tune - Basic research in cardiology, 2003 - Springer
■ Abstract This study tested whether the pre-diabetic metabolic syndrome impairs coronary
blood flow control sufficiently to alter the balance between coronary blood flow and …

Fetal anemia leads to augmented contractile response to hypoxic stress in adulthood

CS Broberg, GD Giraud, JM Schultz… - American Journal …, 2003 - journals.physiology.org
In response to chronic fetal anemia, coronary blood flow, maximal coronary conductance,
and coronary reserve increase. We sought to determine whether chronic fetal anemia alters …

Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm

HMO Farouque, IT Meredith - Clinical Science, 2003 - portlandpress.com
Experimental data suggest that vascular ATP-sensitive potassium (KATP) channels may be
an important determinant of functional hyperaemia, but the contribution of KATP channels to …

Relative contribution of vasodilator prostanoids, NO, and KATP channels to human forearm metabolic vasodilation

HMO Farouque, IT Meredith - American Journal of …, 2003 - journals.physiology.org
Isolated ATP-sensitive K+ (KATP) channel inhibition with glibenclamide does not alter
exercise-induced forearm metabolic vasodilation. Whether forearm metabolic vasodilation …

[PDF][PDF] KATP channels in vascular smooth muscle: structure, regulation and functional roles

NB Standen - Journal of Clinical and Basic Cardiology, 2003 - kup.at
It is rather over a decade since vascular ATP-sensitive potassium (KATP) channels were first
identified. Since then these channels have been the subject of extensive research, and …

Inhibition of vascular ATP-sensitive K+channels does not affect reactive hyperemia in human forearm

HMO Farouque, IT Meredith - American Journal of …, 2003 - journals.physiology.org
The extent to which ATP-sensitive K+ channels contribute to reactive hyperemia in humans
is unresolved. We examined the role of ATP-sensitive K+ channels in regulating reactive …