Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure‐induced neurogenesis in the dentate gyrus

A Mazarati, X Lu, K Kilk, Ü Langel… - European Journal of …, 2004 - Wiley Online Library
The neuropeptide galanin has been implicated in inhibiting seizures and protecting
hippocampal neurons from excitotoxic injury. In the hippocampus galanin acts through two …

Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice

B Ahrén, G Pacini, D Wynick, N Wierup… - Endocrinology, 2004 - academic.oup.com
The neuropeptide galanin is expressed in sympathetic nerve terminals that surround islet
cells and inhibits insulin secretion. To explore its role for islet function, we studied mice with …

Neurotrophic influences on neuropathic pain

SB McMahon, WBJ Cafferty - Pathological Pain: From …, 2004 - Wiley Online Library
Damage to peripheral nerves following trauma or disease has a number of consequences
including the emergence of neuropathic pain. Commonly, neuropathic pain sufferers …

Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5

XY Hua, CS Hayes, A Hofer, B Fitzsimmons… - … of Pharmacology and …, 2004 - ASPET
The neuropeptide galanin (Gal) and its receptors (GalR1, GalR2, and GalR3) are expressed
in spinal cord. We have characterized the pharmacology of the antinociceptive effects of …

Pro-nociceptive role of peripheral galanin in inflammatory pain

JM Jimenez-Andrade, S Zhou, J Du, A Yamani… - Pain, 2004 - Elsevier
We investigated the peripheral function of galanin (GAL) in capsaicin (CAP)-induced
inflammatory pain. Intraplantar GAL (0.1 ng/μl) alone does not produce nociceptive …

Galanin and cognition

JK Robinson - Behavioral and Cognitive Neuroscience …, 2004 - journals.sagepub.com
Since the neuropeptide galanin's discovery in 1983, information has accumulated that
implicates it in a wide range of functions, including pain sensation, stress responses …

Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin

JG Hohmann, DN Teklemichael… - … and cellular biology, 2004 - Am Soc Microbiol
Neuropeptide Y (NPY) and galanin have both been implicated in the regulation of body
weight, yet mice bearing deletions of either of these molecules have unremarkable …

Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury

K Hygge-Blakeman, P Brumovsky, JX Hao, XJ Xu… - Brain research, 2004 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …

An in vivo mouse spinal cord preparation for patch-clamp analysis of nociceptive processing

BA Graham, AM Brichta, RJ Callister - Journal of neuroscience methods, 2004 - Elsevier
The laboratory mouse is now considered the preferred mammalian species for molecular
and genetic analysis in neurobiology. In part, this is due to the existence, in the mouse, of …

Functional organization of dorsal horn interneurons

WD Willis, RE Coggeshall, WD Willis… - Sensory Mechanisms of …, 2004 - Springer
Sensory processing in the spinal cord involves interactions among primary afferent fibers
bearing information from sensory receptors, interneurons, ascending tract cells conveying …