Modulation of chromatin structure through histone acetylation/deacetylation is known to be
one of the major mechanisms involved in the regulation of gene expression. Two opposing …

Histone deacetylase inhibitors (HDACi) are a promising new class of chemotherapeutic drug
currently in early phase clinical trials. A large number of structurally diverse HDACi have …

Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a
potent inducer of phase 2 detoxification enzymes and inhibits tumorigenesis in animal …

Histone deacetylases (HDACs) affect cell growth at the transcriptional level by regulating the
acetylation status of nucleosomal histones. HDAC inhibition induces differentiation and/or …

Present studies demonstrate that treatment with the histone deacetylases inhibitor LAQ824,
a cinnamic acid hydroxamate, increased the acetylation of histones H3 and H4, as well as …

New therapies are required for chronic lymphocytic leukemia (CLL), an incurable disease
characterized by failure of mature lymphocytes to undergo apoptosis. Activation of cell …

We have synthesized a histone deacetylase inhibitor, NVP-LAQ824, a cinnamic hydroxamic
acid, that inhibited in vitro enzymatic activities and transcriptionally activated the p21 …

Acetylation and deacetylation of nucleosomal histones play an important role in the
modulation of chromatin structure, chromatin function and in the regulation of gene …

Multiple myeloma (MM) is a neoplastic proliferation of plasma cells and remains an
incurable disease because of the development of drug resistance. Histone deacytylase …

HDAC inhibitors induce histone hyperacetylation by a relative increase of histone
acetyltransferase activity. Histone hyperacetylation may affect chromatin structure and …