Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view
T Vanhaecke, P Papeleu, G Elaut… - Current medicinal …, 2004 - ingentaconnect.com
Modulation of chromatin structure through histone acetylation/deacetylation is known to be
one of the major mechanisms involved in the regulation of gene expression. Two opposing …
one of the major mechanisms involved in the regulation of gene expression. Two opposing …
Histone-deacetylase inhibitors for the treatment of cancer
RK Lindemann, B Gabrielli, RW Johnstone - Cell cycle, 2004 - Taylor & Francis
Histone deacetylase inhibitors (HDACi) are a promising new class of chemotherapeutic drug
currently in early phase clinical trials. A large number of structurally diverse HDACi have …
currently in early phase clinical trials. A large number of structurally diverse HDACi have …
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
MC Myzak, PA Karplus, FL Chung, RH Dashwood - Cancer research, 2004 - AACR
Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a
potent inducer of phase 2 detoxification enzymes and inhibits tumorigenesis in animal …
potent inducer of phase 2 detoxification enzymes and inhibits tumorigenesis in animal …
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications
CS Mitsiades, NS Mitsiades… - Proceedings of the …, 2004 - National Acad Sciences
Histone deacetylases (HDACs) affect cell growth at the transcriptional level by regulating the
acetylation status of nucleosomal histones. HDAC inhibition induces differentiation and/or …
acetylation status of nucleosomal histones. HDAC inhibition induces differentiation and/or …
Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling …
F Guo, C Sigua, J Tao, P Bali, P George, Y Li… - Cancer research, 2004 - AACR
Present studies demonstrate that treatment with the histone deacetylases inhibitor LAQ824,
a cinnamic acid hydroxamate, increased the acetylation of histones H3 and H4, as well as …
a cinnamic acid hydroxamate, increased the acetylation of histones H3 and H4, as well as …
Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies
S Inoue, M MacFarlane, N Harper, LMC Wheat… - Cell Death & …, 2004 - nature.com
New therapies are required for chronic lymphocytic leukemia (CLL), an incurable disease
characterized by failure of mature lymphocytes to undergo apoptosis. Activation of cell …
characterized by failure of mature lymphocytes to undergo apoptosis. Activation of cell …
Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824
P Atadja, L Gao, P Kwon, N Trogani, H Walker, M Hsu… - Cancer Research, 2004 - AACR
We have synthesized a histone deacetylase inhibitor, NVP-LAQ824, a cinnamic hydroxamic
acid, that inhibited in vitro enzymatic activities and transcriptionally activated the p21 …
acid, that inhibited in vitro enzymatic activities and transcriptionally activated the p21 …
Role of histone deacetylase inhibitors in the treatment of cancer
S Mei, AD Ho, U Mahlknecht - … journal of oncology, 2004 - spandidos-publications.com
Acetylation and deacetylation of nucleosomal histones play an important role in the
modulation of chromatin structure, chromatin function and in the regulation of gene …
modulation of chromatin structure, chromatin function and in the regulation of gene …
Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma
SB Khan, T Maududi, K Barton… - British journal of …, 2004 - Wiley Online Library
Multiple myeloma (MM) is a neoplastic proliferation of plasma cells and remains an
incurable disease because of the development of drug resistance. Histone deacytylase …
incurable disease because of the development of drug resistance. Histone deacytylase …
Histone deacetylase inhibitors FK228, N‐(2‐aminophenyl)‐4‐[N‐(pyridin‐3‐yl‐methoxycarbonyl)amino‐ methyl]benzamide and m‐carboxycinnamic acid bis …
Y Zhang, M Adachi, X Zhao… - … journal of cancer, 2004 - Wiley Online Library
HDAC inhibitors induce histone hyperacetylation by a relative increase of histone
acetyltransferase activity. Histone hyperacetylation may affect chromatin structure and …
acetyltransferase activity. Histone hyperacetylation may affect chromatin structure and …