▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

The φC31 integrase functions efficiently in vitro and in Escherichia coli, yeast, and
mammalian cells, mediating unidirectional site-specific recombination between its attB and …

Incomplete retinal vascularization occurs in both Norrie disease and familial exudative
vitreoretinopathy (FEVR). Norrin, the protein product of the Norrie disease gene, is a …

Recent revelations that the canonical Wnt signaling pathway promotes postnatal bone
accrual are major advances in our understanding of skeletal biology and bring tremendous …

LDL receptor related proteins 5 and 6 (LRP5/6) and their Drosophila homolog Arrow are
single-span transmembrane proteins essential for Wnt/β-catenin signaling, likely via acting …

B cell chronic lymphocytic leukemia (CLL) is characterized by an accumulation of mature,
functionally incompetent B cells. Wnts are a large family of secreted glycoproteins involved …

Frizzled genes encode integral membrane proteins that function in multiple signal
transduction pathways. They have been identified in diverse animals, from sponges to …

The Ryk receptor belongs to the atypical receptor tyrosine kinase family. It is a new member
of the family of Wnt receptor proteins. However, the molecular mechanisms by which the Ryk …

Wnt-induced signaling via β-catenin plays crucial roles in animal development and
tumorigenesis. Both a seven-transmembrane protein in the Frizzled family and a single …