Mammalian circadian biology: elucidating genome-wide levels of temporal organization
PL Lowrey, JS Takahashi - Annu. Rev. Genomics Hum. Genet., 2004 - annualreviews.org
▪ Abstract During the past decade, the molecular mechanisms underlying the mammalian
circadian clock have been defined. A core set of circadian clock genes common to most cells …
circadian clock have been defined. A core set of circadian clock genes common to most cells …
Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei
MH Hastings, ED Herzog - Journal of biological rhythms, 2004 - journals.sagepub.com
The mammalian SCN contains a biological clock that drives remarkably precise circadian
rhythms in vivo and in vitro. Recent advances have revealed molecular and cellular …
rhythms in vivo and in vitro. Recent advances have revealed molecular and cellular …
Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells
E Nagoshi, C Saini, C Bauer, T Laroche, F Naef… - Cell, 2004 - cell.com
The mammalian circadian timing system is composed of a central pacemaker in the
suprachiasmatic nucleus (SCN) of the brain and subsidiary oscillators in most peripheral cell …
suprachiasmatic nucleus (SCN) of the brain and subsidiary oscillators in most peripheral cell …
Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy
Classic experiments have shown that ovulation and estrous cyclicity are under circadian
control and that surgical ablation of the suprachiasmatic nuclei (SCN) results in estrous …
control and that surgical ablation of the suprachiasmatic nuclei (SCN) results in estrous …
Modeling feedback loops of the mammalian circadian oscillator
The suprachiasmatic nucleus governs daily variations of physiology and behavior in
mammals. Within single neurons, interlocked transcriptional/translational feedback loops …
mammals. Within single neurons, interlocked transcriptional/translational feedback loops …
Transcription regulation within the circadian clock: the E-box and beyond
PE Hardin - Journal of biological rhythms, 2004 - journals.sagepub.com
The circadian oscillator is composed of transcriptional feedback loops in organisms ranging
from cyanobacteria to humans. These transcriptional feedback loops are so named because …
from cyanobacteria to humans. These transcriptional feedback loops are so named because …
Direct association between mouse PERIOD and CKIε is critical for a functioning circadian clock
The mPER1 and mPER2 proteins have important roles in the circadian clock mechanism,
whereas mPER3 is expendable. Here we examine the posttranslational regulation of …
whereas mPER3 is expendable. Here we examine the posttranslational regulation of …
E-box function in a period gene repressed by light
D Vallone, SB Gondi, D Whitmore… - Proceedings of the …, 2004 - National Acad Sciences
In most organisms, light plays a key role in the synchronization of the circadian timing
system with the environmental day–night cycle. Light pulses that phase-shift the circadian …
system with the environmental day–night cycle. Light pulses that phase-shift the circadian …
Insight into molecular core clock mechanism of embryonic and early postnatal rat suprachiasmatic nucleus
M Sládek, A Sumová, Z Kováčiková… - Proceedings of the …, 2004 - National Acad Sciences
Rhythmicity of the rat suprachiasmatic nucleus (SCN), a site of the circadian clock, develops
prenatally. A molecular clockwork responsible for the rhythmicity consists of clock genes and …
prenatally. A molecular clockwork responsible for the rhythmicity consists of clock genes and …
Clock genes in cell clocks: roles, actions, and mysteries
H Okamura - Journal of Biological Rhythms, 2004 - journals.sagepub.com
Cellular events must be organized in the time dimension as well as in the space dimension
for many proteins to perform their cellular functions effectively. The intracellular molecular …
for many proteins to perform their cellular functions effectively. The intracellular molecular …