DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …

La famille de facteurs de transcription Sp partage une combinaison particulière de trois
motifs à doigts de zinc Cys2His2 qui forment le domaine spécifique de liaison à l'ADN. Au …

The imprinted regulation of H19 and Insulin-like growth factor 2 expression involves binding
of the vertebrate insulator protein, CCCTC binding factor (CTCF), to the maternally …

The basis for the endothelial cell-restricted expression of endothelial nitric-oxide synthase
(eNOS) is not known. While transgenic promoter/reporter mice demonstrated endothelium …

ABSTRACT DNA methylation contributes to the chromatin conformation that represses
transcription of human papillomavirus type16 (HPV-16), which is prevalent in the etiology of …

Several male germ line-specific genes, including MAGE-A1, rely on DNA methylation for
their repression in normal somatic tissues. These genes become activated in many types of …

Results Of the 127 cancer-free samples, methylation was detected in 6% for p16, 13% for
RARß, 3% for H-cadherin, 4% for RASSF1A, and 28% for FHIT. Hypermethylation of the p16 …

A∼ 2.4-kb imprinting control region (ICR) regulates somatic monoallelic expression of the
Igf2 and H19 genes. This is achieved through DNA methylation-dependent chromatin …

DNA methylation has been implicated in mammalian development. Transcription units
contain CpG islands, but expression of CpG island associated genes in normal tissues was …

Uteroplacental insufficiency and subsequent intrauterine growth retardation (IUGR) increase
the risk of adult onset insulin resistance and dyslipidemia in humans and rats. IUGR rats are …